Sóng đứng là gì? Các bài báo nghiên cứu khoa học liên quan

Định nghĩa sóng đứng

Sóng đứng là hiện tượng giao thoa của hai sóng cùng biên độ và tần số truyền ngược chiều nhau trên cùng một phương truyền, tạo ra một mô hình dao động cố định không gian. Các điểm trên phương truyền mà biên độ dao động luôn bằng không gọi là nút (node), trong khi các điểm có biên độ cực đại gọi là bụng sóng (antinode).

Không giống sóng tiến, sóng đứng không vận chuyển năng lượng theo phương truyền sóng mà chỉ dao động tại chỗ; năng lượng chủ yếu biến đổi giữa thế năng và động năng của môi trường. Sóng đứng xuất hiện phổ biến trong các hệ vật lý có biên cố định như dây đàn, ống cộng hưởng âm thanh hoặc buồng cộng hưởng sóng điện từ.

Các điều kiện để sóng đứng hình thành bao gồm: hai sóng gốc và phản xạ phải có tần số và biên độ bằng nhau, pha tương quan theo quy luật phản xạ (cùng pha hoặc ngược pha tùy tính chất biên) và môi trường phải cho phép hai sóng gặp nhau giao thoa liên tục. Mẫu dao động thu được cố định không gian nhưng thay đổi biên độ theo thời gian với tần số bằng tần số kích thích.

• Node (nút): vị trí biên độ = 0, dao động bằng không.
• Antinode (bụng sóng): vị trí biên độ cực đại.
• Khoảng cách giữa hai node/antinode kế tiếp: $\tfrac{\lambda}{2}$.

Nguyên lý hình thành

Khi hai sóng tiến và sóng phản xạ với cùng biên độ A và tần số ω truyền ngược chiều nhau, chúng gặp nhau trên cùng phương truyền và cộng hưởng xây dựng mô hình sóng đứng. Sóng phản xạ xuất phát từ biên ràng buộc, có thể là biên cố định (ngược pha) hoặc biên tự do (cùng pha).

Sóng tiến ban đầu có dạng $y_1=A\sin(kx - \omega t)$, sóng phản xạ ngược chiều có dạng $y_2=A\sin(kx + \omega t + \phi)$ với φ phụ thuộc điều kiện biên. Tổng hợp hai thành phần này theo nguyên lý chồng chất sóng tạo ra sóng đứng.

• Biên cố định (ví dụ đầu dây căng): sóng phản xạ ngược pha (φ = π).
• Biên tự do (ví dụ đầu ống mở): sóng phản xạ cùng pha (φ = 0).
• Mẫu dao động không gian cố định, chỉ thay đổi biên độ theo hàm cos(ωt) hoặc sin(ωt).

Chính nhờ sự phản xạ và giao thoa bền vững, sóng đứng có thể duy trì lâu dài nếu mất mát năng lượng nhỏ hoặc được bù đắp qua nguồn kích thích liên tục. Đó là lý do sóng đứng quan trọng trong cộng hưởng âm thanh, cộng hưởng điện từ và dao động cơ học.

Phương trình toán học

Sóng tiến: $y_1 = A\sin(kx - \omega t)$
Sóng ngược chiều: $y_2 = A\sin(kx + \omega t)$. Cộng hai sóng:

y = y_1 + y_2 = A\sin(kx - \omega t) + A\sin(kx + \omega t) \end{math/tex}

Sử dụng công thức cộng sin, ta có:

$y = 2A\sin(kx)\cos(\omega t) \end{math/tex}</p> <p>Công thức này cho thấy biên độ dao động tại mỗi vị trí x tỉ lệ với <script type="math/tex">\sin(kx)</span>, còn dao động theo thời gian t là hàm cos với tần số ω. Điều kiện cộng hưởng trên chiều dài L của hệ là:</p><ul><li><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>k</mi><mi>L</mi><mo>=</mo><mi>n</mi><mi>π</mi><mo separator="true">,</mo><mspace width="1em"/><mi>n</mi><mo>∈</mo><mi mathvariant="double-struck">N</mi></mrow><annotation encoding="application/x-tex">kL = n\pi,\quad n\in\mathbb{N}</annotation></semantics></math></span></span> (dây hai đầu cố định hoặc ống hai đầu mở).</li><li>Tần số cộng hưởng: <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><msub><mi>f</mi><mi>n</mi></msub><mo>=</mo><mfrac><mi>n</mi><mrow><mn>2</mn><mi>L</mi></mrow></mfrac><mtext> </mtext><mi>v</mi></mrow><annotation encoding="application/x-tex">f_n = \frac{n}{2L}\,v</annotation></semantics></math></span></span> với v là vận tốc sóng.</li></ul><p>Phương trình tổng quát <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>y</mi><mo stretchy="false">(</mo><mi>x</mi><mo separator="true">,</mo><mi>t</mi><mo stretchy="false">)</mo><mo>=</mo><mn>2</mn><mi>A</mi><mi>sin</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>k</mi><mi>x</mi><mo stretchy="false">)</mo><mi>cos</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>ω</mi><mi>t</mi><mo stretchy="false">)</mo></mrow><annotation encoding="application/x-tex">y(x,t) = 2A\sin(kx)\cos(\omega t)</annotation></semantics></math></span></span> là cơ sở phân tích nút, bụng sóng và tính toán phổ cộng hưởng cho mọi hệ sóng đứng.</p><h2>Nút và bụng sóng</h2><p>Node (nút) là vị trí x thoả mãn <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>sin</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>k</mi><mi>x</mi><mo stretchy="false">)</mo><mo>=</mo><mn>0</mn></mrow><annotation encoding="application/x-tex">\sin(kx)=0</annotation></semantics></math></span></span>, do đó biên độ dao động luôn bằng không. Khoảng cách giữa hai nút liên tiếp bằng <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mfrac><mi>λ</mi><mn>2</mn></mfrac></mrow><annotation encoding="application/x-tex">\frac{\lambda}{2}</annotation></semantics></math></span></span>, cho phép chia đường truyền thành các đoạn cố định.</p><p>Antinode (bụng sóng) là vị trí x thoả mãn <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi mathvariant="normal">∣</mi><mi>sin</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>k</mi><mi>x</mi><mo stretchy="false">)</mo><mi mathvariant="normal">∣</mi><mo>=</mo><mn>1</mn></mrow><annotation encoding="application/x-tex">|\sin(kx)|=1</annotation></semantics></math></span></span>, tại đó biên độ dao động đạt cực đại = 2A. Khoảng cách giữa hai bụng sóng kế tiếp cũng bằng <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mfrac><mi>λ</mi><mn>2</mn></mfrac></mrow><annotation encoding="application/x-tex">\frac{\lambda}{2}</annotation></semantics></math></span></span>, và bụng sóng luôn nằm giữa hai nút.</p><figure class="table"><table><thead><tr><th>Đặc điểm</th><th>Công thức</th><th>Giải thích</th></tr></thead><tbody><tr><td>Nút (Node)</td><td><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>sin</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>k</mi><mi>x</mi><mo stretchy="false">)</mo><mo>=</mo><mn>0</mn></mrow><annotation encoding="application/x-tex">\sin(kx)=0</annotation></semantics></math></span></span></td><td>Biên độ = 0, không dao động</td></tr><tr><td>Bụng sóng (Antinode)</td><td><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi mathvariant="normal">∣</mi><mi>sin</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>k</mi><mi>x</mi><mo stretchy="false">)</mo><mi mathvariant="normal">∣</mi><mo>=</mo><mn>1</mn></mrow><annotation encoding="application/x-tex">|\sin(kx)|=1</annotation></semantics></math></span></span></td><td>Biên độ = 2A, dao động cực đại</td></tr><tr><td>Khoảng cách</td><td><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mfrac><mi>λ</mi><mn>2</mn></mfrac></mrow><annotation encoding="application/x-tex">\frac{\lambda}{2}</annotation></semantics></math></span></span></td><td>Giữa hai nút hoặc hai bụng sóng liên tiếp</td></tr></tbody></table></figure><p>Việc xác định chính xác vị trí nút và bụng sóng trong thực nghiệm giúp thiết kế nhạc cụ dây, buồng âm cộng hưởng và các thiết bị cảm biến dao động cơ học, âm học, điện từ.</p><h2>Sóng đứng trên dây căng</h2><p>Dây căng hai đầu cố định hỗ trợ hình thành sóng đứng khi sóng tiến và sóng phản xạ giao thoa. Điều kiện biên yêu cầu tại hai đầu của dây, dao động phải bằng không (nút), nên chiều dài L của dây phải chứa nguyên số n⁄2 bước sóng:</p><ul><li><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>L</mi><mo>=</mo><mfrac><mrow><mi>n</mi><mi>λ</mi></mrow><mn>2</mn></mfrac><mo separator="true">,</mo><mspace width="1em"/><mi>n</mi><mo>=</mo><mn>1</mn><mo separator="true">,</mo><mn>2</mn><mo separator="true">,</mo><mn>3</mn><mo separator="true">,</mo><mo>…</mo></mrow><annotation encoding="application/x-tex">L = \frac{n\lambda}{2},\quad n=1,2,3,\dots</annotation></semantics></math></span></span></li><li>Tần số cộng hưởng: <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><msub><mi>f</mi><mi>n</mi></msub><mo>=</mo><mfrac><mrow><mi>n</mi><mtext> </mtext><mi>v</mi></mrow><mrow><mn>2</mn><mi>L</mi></mrow></mfrac></mrow><annotation encoding="application/x-tex">f_n = \frac{n\,v}{2L}</annotation></semantics></math></span></span>, với v là vận tốc sóng trên dây.</li></ul><p>Vận tốc sóng trên dây phụ thuộc mật độ khối ρ và lực căng T theo công thức <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>v</mi><mo>=</mo><msqrt><mfrac><mi>T</mi><mrow><mi>ρ</mi><mi>A</mi></mrow></mfrac></msqrt></mrow><annotation encoding="application/x-tex">v=\sqrt{\tfrac{T}{\rho A}}</annotation></semantics></math></span></span>, trong đó A là tiết diện dây. Do đó, siết chặt dây (tăng T) hay thay đổi khối lượng riêng cho phép điều chỉnh phổ cộng hưởng.</p><h2>Sóng đứng trong ống cộng hưởng</h2><p>Ống âm thanh tạo sóng đứng khi sóng âm tiến và phản xạ tại hai đầu ống. Với ống mở cả hai đầu, cả hai đầu là bụng sóng, bước sóng phải thỏa mãn <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>L</mi><mo>=</mo><mi>n</mi><mfrac><mi>λ</mi><mn>2</mn></mfrac></mrow><annotation encoding="application/x-tex">L = n\frac{\lambda}{2}</annotation></semantics></math></span></span>. Ống kín–một đầu cho bộ cộng hưởng khác, chỉ bụng tại đầu mở và nút tại đầu kín:</p><ul><li>Ống mở: <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><msub><mi>f</mi><mi>n</mi></msub><mo>=</mo><mfrac><mrow><mi>n</mi><mtext> </mtext><mi>v</mi></mrow><mrow><mn>2</mn><mi>L</mi></mrow></mfrac><mo separator="true">,</mo><mspace width="1em"/><mi>n</mi><mo>=</mo><mn>1</mn><mo separator="true">,</mo><mn>2</mn><mo separator="true">,</mo><mn>3</mn><mo separator="true">,</mo><mo>…</mo></mrow><annotation encoding="application/x-tex">f_n=\frac{n\,v}{2L},\quad n=1,2,3,\dots</annotation></semantics></math></span></span></li><li>Ống kín–một đầu: <span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><msub><mi>f</mi><mi>n</mi></msub><mo>=</mo><mfrac><mrow><mo stretchy="false">(</mo><mn>2</mn><mi>n</mi><mo>−</mo><mn>1</mn><mo stretchy="false">)</mo><mtext> </mtext><mi>v</mi></mrow><mrow><mn>4</mn><mi>L</mi></mrow></mfrac><mo separator="true">,</mo><mspace width="1em"/><mi>n</mi><mo>=</mo><mn>1</mn><mo separator="true">,</mo><mn>2</mn><mo separator="true">,</mo><mn>3</mn><mo separator="true">,</mo><mo>…</mo></mrow><annotation encoding="application/x-tex">f_n=\frac{(2n-1)\,v}{4L},\quad n=1,2,3,\dots</annotation></semantics></math></span></span></li></ul><p>Ứng dụng thực tế gồm kèn ống, sáo, ống cộng hưởng sonar, nơi điều chỉnh chiều dài L để thay đổi tần số phát âm.</p><h2>Sóng điện từ đứng</h2><p>Trong buồng cộng hưởng sóng điện từ (microwave cavity), sóng phản xạ trên thành kim loại tạo ra trường điện từ đứng. Phương trình Maxwell dẫn tới phân bố điện trường E và từ trường B tuân theo:</p><p><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>E</mi><mo stretchy="false">(</mo><mi>x</mi><mo separator="true">,</mo><mi>t</mi><mo stretchy="false">)</mo><mo>=</mo><msub><mi>E</mi><mn>0</mn></msub><mi>sin</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>k</mi><mi>x</mi><mo stretchy="false">)</mo><mi>cos</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>ω</mi><mi>t</mi><mo stretchy="false">)</mo><mo separator="true">,</mo><mspace width="1em"/><mi>B</mi><mo stretchy="false">(</mo><mi>x</mi><mo separator="true">,</mo><mi>t</mi><mo stretchy="false">)</mo><mo>=</mo><msub><mi>B</mi><mn>0</mn></msub><mi>cos</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>k</mi><mi>x</mi><mo stretchy="false">)</mo><mi>sin</mi><mo>⁡</mo><mo stretchy="false">(</mo><mi>ω</mi><mi>t</mi><mo stretchy="false">)</mo></mrow><annotation encoding="application/x-tex">E(x,t)=E_0\sin(kx)\cos(\omega t),\quad B(x,t)=B_0\cos(kx)\sin(\omega t)</annotation></semantics></math></span></span></p><p>Điều kiện biên kim loại yêu cầu thành buồng là nút điện trường (E=0), từ đó tần số cộng hưởng xác định theo kích thước và hình dạng buồng. Ứng dụng trong lò vi sóng, máy đo dielectrics và thí nghiệm quang học lượng tử.</p><h2>Cộng hưởng và tần số cộng hưởng</h2><p>Cộng hưởng xảy ra khi tần số kích thích trùng với một trong các tần số cộng hưởng fₙ, dẫn đến biên độ dao động cực đại. Độ lợi cộng hưởng thể hiện qua hệ số chất lượng Q:</p><p><span class="inline-equation"><span class="katex"><math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>Q</mi><mo>=</mo><mfrac><msub><mi>ω</mi><mn>0</mn></msub><mrow><mi mathvariant="normal">Δ</mi><mi>ω</mi></mrow></mfrac></mrow><annotation encoding="application/x-tex">Q = \frac{\omega_0}{\Delta \omega}</annotation></semantics></math></span></span>, với ω₀ là tần số cộng hưởng chính và Δω băng thông tại biên độ giảm √2/2.</p><p>Trong thực tế, hệ số Q cao giúp dao động bền vững lâu nhưng dễ gây quá dao động; Q thấp khắc phục dao động dư, thích hợp cho hệ giảm chấn và thiết bị chống cộng hưởng.</p><h2>Ứng dụng trong kỹ thuật và khoa học</h2><p>Sóng đứng được tận dụng trong thiết kế nhạc cụ dây (đàn guitar, violon), ống thổi (kèn, sáo) và buồng vọng âm thanh. Trong y sinh, sóng siêu âm đứng tạo vùng áp suất thay đổi để đo mật độ mô hoặc phá huỷ tế bào ung thư.</p><p>Trong công nghiệp, cộng hưởng cơ khí dùng để đo vận tốc sóng và xác định mô đun đàn hồi vật liệu thông qua phân tích tần số cộng hưởng. Sóng đứng trong ống và buồng cộng hưởng cũng ứng dụng làm cảm biến áp suất, lưu lượng chất lỏng và khí.</p><h2>Phương pháp đo và quan sát</h2><p>Laser Doppler Vibrometry (LDV) đo biên độ dao động tại nút và bụng sóng trên bề mặt vật thể. Kỹ thuật này không tiếp xúc, cho phép ghi lại modal shapes và tần số cộng hưởng với độ phân giải cao.</p><p>Phần mềm phần tử hữu hạn (FEM) mô phỏng modal analysis để dự đoán vị trí nút–bụng và phổ tần số cộng hưởng. So sánh kết quả số và dữ liệu thực nghiệm qua vibrometer giúp hiệu chỉnh mô hình và vật liệu.</p><ul><li>Quan sát trực tiếp: gắn cảm biến gia tốc hoặc vi đo rung.</li><li>Hệ thống camera tốc độ cao: ghi ảnh chuyển động của vạch sơn trên dây/ống.</li><li>Phân tích phổ FFT: xác định tần số cộng hưởng từ tín hiệu dao động.</li></ul><h2>Tài liệu tham khảo</h2><ol><li>HyperPhysics. “Standing Waves.” Georgia State University. <a href="http://hyperphysics.phy-astr.gsu.edu/hbase/Waves/standing.html">hyperphysics.phy-astr.gsu.edu</a></li><li>Hecht, E. <i>Optics</i>. Addison-Wesley, 2002.</li><li>Fletcher, N. H., Rossing, T. D. <i>The Physics of Musical Instruments</i>. Springer, 1998.</li><li>Kinsler, L. E., Frey, A. R., Coppens, A. B., Sanders, J. V. <i>Fundamentals of Acoustics</i>. Wiley, 2000.</li><li>Sakamoto, S., et al. “Microwave Cavity Resonators: Theory and Applications.” <i>IEEE Trans. Microw. Theory Techn.</i>, 2015. <a href="https://ieeexplore.ieee.org/document/7108330">IEEE Xplore</a></li></ol></div><div class="el-divider el-divider--horizontal" style="--el-border-style:solid;" role="separator"><!--v-if--></div><h2>Các bài báo, nghiên cứu, công bố khoa học về chủ đề sóng đứng:</h2><div><div><!--[--><div class="entity-item-container" data-v-d071913d><a href="/publication/Phase-III-Study-of-Afatinib-or-Cisplatin-Plus-Pemetrexed-in-Patients-With-Metastatic-Lung-Adenocarcinoma-With-i-EGFR-i-Mutations/9b7a8356-222e-46dc-95be-f551c4551a4f" class="entity-title" data-v-d071913d><span data-v-d071913d>Nghiên cứu giai đoạn III về Afatinib hoặc Cisplatin kết hợp Pemetrexed ở bệnh nhân ung thư tuyến phổi di căn với đột biến EGFR</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>American Society of Clinical Oncology (ASCO)</span> - </span> Tập 31 Số 27 <span data-v-d071913d> - Trang 3327-3334</span><span data-v-d071913d> - 2013</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:sec><jats:title>Mục tiêu</jats:title><jats:p>Nghiên cứu LUX-Lung 3 đã khảo sát hiệu quả của hóa trị so với afatinib, một chất ức chế có khả năng phong tỏa tín hiệu không hồi phục từ thụ thể yếu tố tăng trưởng biểu bì (EGFR/ErbB1), thụ thể 2 (HER2/ErbB2) và ErbB4. Afatinib cho thấy khả năng hoạt động rộng rãi đối với các đột biến EGFR. Nghiên cứu giai đoạn II về afatinib ở ung thư tuyến phổi ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Afatinib<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #cisplatin<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #pemetrexed<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #adenocarcinoma phổi<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #đột biến EGFR<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sống không tiến triển<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #hóa trị<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #giảm đau<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #kiểm soát triệu chứng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #đột biến exon 19<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #L858R<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tác dụng phụ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nghiên cứu lâm sàng giai đoạn III<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 2936<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://ascopubs.org/doi/10.1200/JCO.2012.44.2806" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/The-development-of-a-walkability-index-application-to-the-Neighborhood-Quality-of-Life-Study/e96086cb-519e-47d1-866e-4c8c9cdfbd4d" class="entity-title" data-v-d071913d><span data-v-d071913d>Phát triển chỉ số đi bộ: ứng dụng cho Nghiên cứu Chất lượng Cuộc sống Khu phố</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>British Journal of Sports Medicine</span> - </span> Tập 44 Số 13 <span data-v-d071913d> - Trang 924-933</span><span data-v-d071913d> - 2010</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p>Các bằng chứng mới nổi hỗ trợ mối liên hệ giữa môi trường xây dựng khu phố và hoạt động thể chất. Cần có các phương pháp hệ thống để đặc trưng hóa môi trường xây dựng khu phố tận dụng thông tin về dân số có sẵn như nhân khẩu học ở cấp độ điều tra dân số. Dựa trên tài liệu về giao thông và quy hoạch đô thị, một chỉ số tích hợp cho việc hiện thực hóa khả năng đi bộ bằng cách sử dụng thông ti...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #môi trường xây dựng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #hoạt động thể chất<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #khả năng đi bộ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #chỉ số đi bộ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nghiên cứu chất lượng cuộc sống khu phố<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 1078<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://bjsm.bmj.com/lookup/doi/10.1136/bjsm.2009.058701" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Long-term-findings-from-COMFORT-II-a-phase-3-study-of-ruxolitinib-vs-best-available-therapy-for-myelofibrosis/24079142-8be0-446b-a669-803f03c32a5d" class="entity-title" data-v-d071913d><span data-v-d071913d>Kết quả dài hạn từ nghiên cứu COMFORT-II, thử nghiệm giai đoạn 3 của ruxolitinib so với liệu pháp tốt nhất có sẵn cho bệnh xơ tủy</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Leukemia</span> - </span> Tập 30 Số 8 <span data-v-d071913d> - Trang 1701-1707</span><span data-v-d071913d> - 2016</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><title>Tóm tắt</title> <p>Ruxolitinib là một chất ức chế Janus kinase (JAK) (JAK1/JAK2) đã cho thấy sự vượt trội hơn so với giả dược và liệu pháp tốt nhất có sẵn (BAT) trong các nghiên cứu Controlled Myelofibrosis Study với điều trị bằng thuốc uống ức chế JAK (COMFORT). COMFORT-II là một nghiên cứu pha 3 ngẫu nhiên (2:1), mở tại những bệnh nhân bị xơ tủy; những bệnh nhân được phân ngẫu nhiên vào nhóm BAT có thể chu...</p></span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #ruxolitinib<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Janus kinase ức chế<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #xơ tủy<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #COMFORT-II<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #khối lượng lách<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tỷ lệ sống còn<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #phân tích giai đoạn 3<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nguy cơ tử vong<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tác dụng phụ<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 447<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://www.nature.com/articles/leu2016148" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/ClustalW-MPI-ClustalW-analysis-using-distributed-and-parallel-computing/364e6298-dba7-4a7d-a367-84a524245db4" class="entity-title" data-v-d071913d><span data-v-d071913d>ClustalW-MPI: Phân tích ClustalW sử dụng tính toán phân tán và song song</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Bioinformatics</span> - </span> Tập 19 Số 12 <span data-v-d071913d> - Trang 1585-1586</span><span data-v-d071913d> - 2003</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title> <jats:p>Tóm lược: ClustalW là một công cụ để căn chỉnh nhiều chuỗi protein hoặc nucleotide. Việc căn chỉnh này được thực hiện thông qua ba bước: căn chỉnh từng cặp, tạo cây hướng dẫn và căn chỉnh tiến dần. ClustalW-MPI là một triển khai phân tán và song song của ClustalW. Cả ba bước đều đã được thực hiện song song để giảm thời gian thực hiện. Phần mềm sử dụng một t...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #ClustalW<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #căn chỉnh chuỗi<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tính toán phân tán<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tính toán song song<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #MPI<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #protein<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nucleotide<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 432<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://academic.oup.com/bioinformatics/article/19/12/1585/257936" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Mineral-trioxide-aggregate-and-other-bioactive-endodontic-cements-an-updated-overview-part-II-other-clinical-applications-and-complications/036d3cba-df5c-4aa7-98f0-79c2633bfa02" class="entity-title" data-v-d071913d><span data-v-d071913d>Hợp chất ba oxit khoáng và các xi măng nội nha sinh học khác: tổng quan cập nhật – phần II: các ứng dụng lâm sàng khác và biến chứng</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>International Endodontic Journal</span> - </span> Tập 51 Số 3 <span data-v-d071913d> - Trang 284-317</span><span data-v-d071913d> - 2018</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title><jats:p>Hợp chất ba oxit khoáng (MTA) là vật liệu nha khoa được sử dụng rộng rãi cho các liệu pháp tủy sống (VPT), bảo vệ các giá đỡ trong các quy trình nội nha tái tạo, tạo rào cản ở các răng có tủy hoại tử và chóp mở, sửa chữa các lỗ thủng cũng như trám bít ống tủy và trám bít chóp răng trong các phẫu thuật nội nha. Gần đây, một số xi măng nội nha sinh học (BECs) ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Hợp chất ba oxit khoáng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #xi măng nội nha sinh học<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #liệu pháp tủy sống<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nội nha tái tạo<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sửa chữa lỗ thủng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tác dụng không mong muốn.<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 353<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://onlinelibrary.wiley.com/doi/10.1111/iej.12843" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Using-residualized-change-versus-difference-scores-for-longitudinal-research/a40239c5-484b-413a-bc1d-ef4af344c2d6" class="entity-title" data-v-d071913d><span data-v-d071913d>Sử dụng mô hình thay đổi dư thừa so với số điểm khác biệt cho nghiên cứu dọc</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Journal of Social and Personal Relationships</span> - </span> Tập 35 Số 1 <span data-v-d071913d> - Trang 32-58</span><span data-v-d071913d> - 2018</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p> Các nhà nghiên cứu quan tâm đến việc nghiên cứu sự thay đổi theo thời gian thường đối mặt với một nghịch lý phân tích: liệu một mô hình thay đổi dư thừa so với một mô hình điểm khác biệt nên được sử dụng để đánh giá tác động của một dự đoán quan trọng đối với sự thay đổi diễn ra giữa hai thời điểm. Trong bài viết này, các tác giả nêu ra một ví dụ thúc đẩy trong đó một nhà nghiên cứu muốn ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nghiên cứu dọc<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #thay đổi dư thừa<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #điểm khác biệt<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nghịch lý Lord<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #mối quan hệ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sống thử<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #sự hài lòng trong mối quan hệ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nghiên cứu không ngẫu nhiên<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #mô hình hóa dữ liệu<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #khung điểm thay đổi tiềm ẩn<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 296<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://journals.sagepub.com/doi/10.1177/0265407517718387" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Determining-the-standoff-distance-of-the-bow-shock-Mach-number-dependence-and-use-of-models/346153ea-473a-4505-9f58-c123ec107d34" class="entity-title" data-v-d071913d><span data-v-d071913d>Xác định khoảng cách đứng yên của sóng sốc mũi: Sự phụ thuộc vào số Mach và việc sử dụng các mô hình</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>American Geophysical Union (AGU)</span> - </span> Tập 99 Số A9 <span data-v-d071913d> - Trang 17681-17689</span><span data-v-d071913d> - 1994</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p>Chúng tôi khảo sát các yếu tố xác định khoảng cách đứng yên của sóng sốc mũi. Những yếu tố này bao gồm các tham số của gió mặt trời, chẳng hạn như số Mach magnetosonic, beta plasma và phương hướng của trường từ, cũng như kích thước và hình dạng của trở ngại. Trong báo cáo này, chúng tôi phát triển một mối quan hệ số Mach bán thực nghiệm cho khoảng cách đứng yên của sóng sốc mũi nhằm tính đ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 283<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://agupubs.onlinelibrary.wiley.com/doi/10.1029/94JA01020" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/A-rapid-non-invasive-procedure-for-quantitative-assessment-of-drought-survival-using-chlorophyll-fluorescence/e3222712-53a2-46f0-a9ce-79261ff1e672" class="entity-title" data-v-d071913d><span data-v-d071913d>Một quy trình nhanh chóng, không xâm lấn để đánh giá định lượng khả năng sống sót trong điều kiện hạn hán bằng cách sử dụng huỳnh quang diệp lục</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Plant Methods</span> - </span> <!----><span data-v-d071913d> - 2008</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title> <jats:sec> <jats:title>Nền tảng</jats:title> <jats:p>Phân tích khả năng sống sót thường được sử dụng như một phương tiện để so sánh hiệu suất của các dòng thực vật dưới điều kiện hạn hán. Tuy nhiên, việc đánh giá tình trạng nước của thực vật trong các nghiên cứu như vậy thường liên quan đến việc tách rời để ước lượng cú sốc nước, n...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Hạn hán<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #khả năng sống sót<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #huỳnh quang diệp lục<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #&lt;jats:italic&gt;Arabidopsis thaliana&lt;/jats:italic&gt;<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #đo không xâm lấn<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 216<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://plantmethods.biomedcentral.com/articles/10.1186/1746-4811-4-27" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Molecular-mechanisms-of-heavy-metal-tolerance-and-evolution-in-invertebrates/e7c66739-495f-40f6-83ee-31a56b0fe661" class="entity-title" data-v-d071913d><span data-v-d071913d>Cơ chế phân tử của khả năng chịu đựng kim loại nặng và sự tiến hóa ở động vật không xương sống</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Insect Science</span> - </span> Tập 16 Số 1 <span data-v-d071913d> - Trang 3-18</span><span data-v-d071913d> - 2009</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title><jats:p>Kể từ khi cách mạng sinh học phân tử diễn ra, kiến thức của chúng ta về các cơ chế phân tử nằm dưới các cơ chế phòng vệ chống lại căng thẳng đã được mở rộng đáng kể. Dưới áp lực chọn lọc mạnh mẽ, nhiều loài động vật có thể tiến hóa để cải thiện khả năng chịu đựng căng thẳng. Điều này có thể đạt được bằng cách thay đổi cấu trúc protein (thông qua các đột biến...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #cơ chế phân tử<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #khả năng chịu đựng kim loại nặng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #động vật không xương sống<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #metallothionein<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #điều chỉnh phiên mã<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 147<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1744-7917.2009.00249.x" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Living-with-and-Building-on-Complexity-A-Constructivist-Perspective-on-Organizations/953c4644-5a17-448d-a38c-0d330351900a" class="entity-title" data-v-d071913d><span data-v-d071913d>Sống Với và Xây Dựng Trên Sự Phức Tạp: Một Góc Nhìn Xây Dựng Về Tổ Chức</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Organization</span> - </span> Tập 5 Số 2 <span data-v-d071913d> - Trang 217-232</span><span data-v-d071913d> - 1998</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p> Bài báo giới thiệu một lý thuyết về tổ chức dựa trên giả định rằng hành vi con người trong các bối cảnh tổ chức là tương đối không xác định, đa chiều và mâu thuẫn. Phù hợp với giả định này, bài báo đề xuất một góc nhìn xây dựng về sự tồn tại, cân bằng và cấu trúc tổ chức. Góc nhìn xây dựng này thể hiện nỗ lực tích hợp các lý thuyết hiện có, và thường được coi là không thể so sánh, về tổ c...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 129<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="http://journals.sagepub.com/doi/10.1177/135050849852004" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><!--]--></div><div class="el-row is-justify-end" style="" data-v-fa649ea5><!--[--><div class="pagination-container" data-v-fa649ea5><span data-v-fa649ea5> Tổng số: 668</span>    <div class="el-pagination is-background" data-v-fa649ea5><button type="button" class="btn-prev is-first" disabled aria-label="Go to previous page" aria-disabled="true"><i class="el-icon" style=""><!--[--><svg 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class="post-page-container"><!--[--><div class="entity-item-container"><a href="/topic/vọng cách" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#vọng cách<!--]--></span><!--v-if--></span><br><p>Vọng cách là gì? Các nghiên cứu khoa học về Vọng cách</p></a></div><div class="entity-item-container"><a href="/topic/đánh giá hiệu suất" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#đánh giá hiệu suất<!--]--></span><!--v-if--></span><br><p>Đánh giá hiệu suất là gì? Các nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/biến dạng" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#biến dạng<!--]--></span><!--v-if--></span><br><p>Biến dạng là gì? Các công bố khoa học về Biến dạng</p></a></div><div class="entity-item-container"><a href="/topic/kháng thể tự động" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#kháng thể tự động<!--]--></span><!--v-if--></span><br><p>Kháng thể tự động là gì? Các nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/cắt bỏ khối u" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#cắt bỏ khối u<!--]--></span><!--v-if--></span><br><p>Cắt bỏ khối u là gì? Các bài nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/bệnh lý mắt graves" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#bệnh lý mắt graves<!--]--></span><!--v-if--></span><br><p>Bệnh lý mắt graves là gì? Các nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/vạt cánh quạt" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#vạt cánh quạt<!--]--></span><!--v-if--></span><br><p>Vạt cánh quạt là gì? Các bài nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/hormone cận giáp" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#hormone cận giáp<!--]--></span><!--v-if--></span><br><p>Hormone cận giáp là gì? Các nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/học máy" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#học máy<!--]--></span><!--v-if--></span><br><p>Học máy là gì? Các bài nghiên cứu khoa học về Học máy</p></a></div><div class="entity-item-container"><a href="/topic/trường vectơ" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#trường vectơ<!--]--></span><!--v-if--></span><br><p>Trường vectơ là gì? 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đứng","Sóng đứng là gì? Các bài báo nghiên cứu khoa học liên quan","Sóng đứng là hiện tượng giao thoa của hai sóng có cùng biên độ và tần số truyền ngược chiều, tạo ra mẫu dao động cố định không gian với nút và bụng sóng. Không truyền năng lượng theo phương truyền mà chỉ dao động tại chỗ, sóng đứng xuất hiện khi điều kiện biên cố định cho phản xạ và giao thoa bền vững. ","\u003Ch2>Định nghĩa sóng đứng\u003C/h2>\u003Cp>Sóng đứng là hiện tượng giao thoa của hai sóng cùng biên độ và tần số truyền ngược chiều nhau trên cùng một phương truyền, tạo ra một mô hình dao động cố định không gian. Các điểm trên phương truyền mà biên độ dao động luôn bằng không gọi là nút (node), trong khi các điểm có biên độ cực đại gọi là bụng sóng (antinode).\u003C/p>\u003Cp>Không giống sóng tiến, sóng đứng không vận chuyển năng lượng theo phương truyền sóng mà chỉ dao động tại chỗ; năng lượng chủ yếu biến đổi giữa thế năng và động năng của môi trường. Sóng đứng xuất hiện phổ biến trong các hệ vật lý có biên cố định như dây đàn, ống cộng hưởng âm thanh hoặc buồng cộng hưởng sóng điện từ.\u003C/p>\u003Cp>Các điều kiện để sóng đứng hình thành bao gồm: hai sóng gốc và phản xạ phải có tần số và biên độ bằng nhau, pha tương quan theo quy luật phản xạ (cùng pha hoặc ngược pha tùy tính chất biên) và môi trường phải cho phép hai sóng gặp nhau giao thoa liên tục. Mẫu dao động thu được cố định không gian nhưng thay đổi biên độ theo thời gian với tần số bằng tần số kích thích.\u003C/p>\u003Cul>\u003Cli>Node (nút): vị trí biên độ = 0, dao động bằng không.\u003C/li>\u003Cli>Antinode (bụng sóng): vị trí biên độ cực đại.\u003C/li>\u003Cli>Khoảng cách giữa hai node/antinode kế tiếp:&nbsp;\u003Cscript type=\"math/tex\">\\tfrac{\\lambda}{2}\u003C/script>.\u003C/li>\u003C/ul>\u003Ch2>Nguyên lý hình thành\u003C/h2>\u003Cp>Khi hai sóng tiến và sóng phản xạ với cùng biên độ A và tần số ω truyền ngược chiều nhau, chúng gặp nhau trên cùng phương truyền và cộng hưởng xây dựng mô hình sóng đứng. Sóng phản xạ xuất phát từ biên ràng buộc, có thể là biên cố định (ngược pha) hoặc biên tự do (cùng pha).\u003C/p>\u003Cp>Sóng tiến ban đầu có dạng&nbsp;\u003Cscript type=\"math/tex\">y_1=A\\sin(kx - \\omega t)\u003C/script>, sóng phản xạ ngược chiều có dạng&nbsp;\u003Cscript type=\"math/tex\">y_2=A\\sin(kx + \\omega t + \\phi)\u003C/script>&nbsp;với φ phụ thuộc điều kiện biên. Tổng hợp hai thành phần này theo nguyên lý chồng chất sóng tạo ra sóng đứng.\u003C/p>\u003Cul>\u003Cli>Biên cố định (ví dụ đầu dây căng): sóng phản xạ ngược pha (φ = π).\u003C/li>\u003Cli>Biên tự do (ví dụ đầu ống mở): sóng phản xạ cùng pha (φ = 0).\u003C/li>\u003Cli>Mẫu dao động không gian cố định, chỉ thay đổi biên độ theo hàm cos(ωt) hoặc sin(ωt).\u003C/li>\u003C/ul>\u003Cp>Chính nhờ sự phản xạ và giao thoa bền vững, sóng đứng có thể duy trì lâu dài nếu mất mát năng lượng nhỏ hoặc được bù đắp qua nguồn kích thích liên tục. Đó là lý do sóng đứng quan trọng trong cộng hưởng âm thanh, cộng hưởng điện từ và dao động cơ học.\u003C/p>\u003Ch2>Phương trình toán học\u003C/h2>\u003Cp>Sóng tiến:&nbsp;\u003Cscript type=\"math/tex\">y_1 = A\\sin(kx - \\omega t)\u003C/script>\u003Cbr>Sóng ngược chiều:&nbsp;\u003Cscript type=\"math/tex\">y_2 = A\\sin(kx + \\omega t)\u003C/script>. Cộng hai sóng:\u003C/p>\u003Cp>\u003Cscript type=\"math/tex\">y = y_1 + y_2 = A\\sin(kx - \\omega t) + A\\sin(kx + \\omega t) \\end{math/tex}\u003C/p> \u003Cp>Sử dụng công thức cộng sin, ta có:\u003C/p> \u003Cp>\u003Cscript type=\"math/tex\"> y = 2A\\sin(kx)\\cos(\\omega t) \\end{math/tex}\u003C/p> \u003Cp>Công thức này cho thấy biên độ dao động tại mỗi vị trí x tỉ lệ với \u003Cscript type=\"math/tex\">\\sin(kx)\u003C/script>, còn dao động theo thời gian t là hàm cos với tần số ω. Điều kiện cộng hưởng trên chiều dài L của hệ là:\u003C/p>\u003Cul>\u003Cli>\u003Cscript type=\"math/tex\">kL = n\\pi,\\quad n\\in\\mathbb{N}\u003C/script>&nbsp;(dây hai đầu cố định hoặc ống hai đầu mở).\u003C/li>\u003Cli>Tần số cộng hưởng:&nbsp;\u003Cscript type=\"math/tex\">f_n = \\frac{n}{2L}\\,v\u003C/script>&nbsp;với v là vận tốc sóng.\u003C/li>\u003C/ul>\u003Cp>Phương trình tổng quát&nbsp;\u003Cscript type=\"math/tex\">y(x,t) = 2A\\sin(kx)\\cos(\\omega t)\u003C/script>&nbsp;là cơ sở phân tích nút, bụng sóng và tính toán phổ cộng hưởng cho mọi hệ sóng đứng.\u003C/p>\u003Ch2>Nút và bụng sóng\u003C/h2>\u003Cp>Node (nút) là vị trí x thoả mãn&nbsp;\u003Cscript type=\"math/tex\">\\sin(kx)=0\u003C/script>, do đó biên độ dao động luôn bằng không. Khoảng cách giữa hai nút liên tiếp bằng&nbsp;\u003Cscript type=\"math/tex\">\\frac{\\lambda}{2}\u003C/script>, cho phép chia đường truyền thành các đoạn cố định.\u003C/p>\u003Cp>Antinode (bụng sóng) là vị trí x thoả mãn&nbsp;\u003Cscript type=\"math/tex\">|\\sin(kx)|=1\u003C/script>, tại đó biên độ dao động đạt cực đại = 2A. Khoảng cách giữa hai bụng sóng kế tiếp cũng bằng&nbsp;\u003Cscript type=\"math/tex\">\\frac{\\lambda}{2}\u003C/script>, và bụng sóng luôn nằm giữa hai nút.\u003C/p>\u003Cfigure class=\"table\">\u003Ctable>\u003Cthead>\u003Ctr>\u003Cth>Đặc điểm\u003C/th>\u003Cth>Công thức\u003C/th>\u003Cth>Giải thích\u003C/th>\u003C/tr>\u003C/thead>\u003Ctbody>\u003Ctr>\u003Ctd>Nút (Node)\u003C/td>\u003Ctd>\u003Cscript type=\"math/tex\">\\sin(kx)=0\u003C/script>\u003C/td>\u003Ctd>Biên độ = 0, không dao động\u003C/td>\u003C/tr>\u003Ctr>\u003Ctd>Bụng sóng (Antinode)\u003C/td>\u003Ctd>\u003Cscript type=\"math/tex\">|\\sin(kx)|=1\u003C/script>\u003C/td>\u003Ctd>Biên độ = 2A, dao động cực đại\u003C/td>\u003C/tr>\u003Ctr>\u003Ctd>Khoảng cách\u003C/td>\u003Ctd>\u003Cscript type=\"math/tex\">\\frac{\\lambda}{2}\u003C/script>\u003C/td>\u003Ctd>Giữa hai nút hoặc hai bụng sóng liên tiếp\u003C/td>\u003C/tr>\u003C/tbody>\u003C/table>\u003C/figure>\u003Cp>Việc xác định chính xác vị trí nút và bụng sóng trong thực nghiệm giúp thiết kế nhạc cụ dây, buồng âm cộng hưởng và các thiết bị cảm biến dao động cơ học, âm học, điện từ.\u003C/p>\u003Ch2>Sóng đứng trên dây căng\u003C/h2>\u003Cp>Dây căng hai đầu cố định hỗ trợ hình thành sóng đứng khi sóng tiến và sóng phản xạ giao thoa. Điều kiện biên yêu cầu tại hai đầu của dây, dao động phải bằng không (nút), nên chiều dài L của dây phải chứa nguyên số n⁄2 bước sóng:\u003C/p>\u003Cul>\u003Cli>\u003Cscript type=\"math/tex\">L = \\frac{n\\lambda}{2},\\quad n=1,2,3,\\dots\u003C/script>\u003C/li>\u003Cli>Tần số cộng hưởng:&nbsp;\u003Cscript type=\"math/tex\">f_n = \\frac{n\\,v}{2L}\u003C/script>, với v là vận tốc sóng trên dây.\u003C/li>\u003C/ul>\u003Cp>Vận tốc sóng trên dây phụ thuộc mật độ khối ρ và lực căng T theo công thức&nbsp;\u003Cscript type=\"math/tex\">v=\\sqrt{\\tfrac{T}{\\rho A}}\u003C/script>, trong đó A là tiết diện dây. Do đó, siết chặt dây (tăng T) hay thay đổi khối lượng riêng cho phép điều chỉnh phổ cộng hưởng.\u003C/p>\u003Ch2>Sóng đứng trong ống cộng hưởng\u003C/h2>\u003Cp>Ống âm thanh tạo sóng đứng khi sóng âm tiến và phản xạ tại hai đầu ống. Với ống mở cả hai đầu, cả hai đầu là bụng sóng, bước sóng phải thỏa mãn&nbsp;\u003Cscript type=\"math/tex\">L = n\\frac{\\lambda}{2}\u003C/script>. Ống kín–một đầu cho bộ cộng hưởng khác, chỉ bụng tại đầu mở và nút tại đầu kín:\u003C/p>\u003Cul>\u003Cli>Ống mở:&nbsp;\u003Cscript type=\"math/tex\">f_n=\\frac{n\\,v}{2L},\\quad n=1,2,3,\\dots\u003C/script>\u003C/li>\u003Cli>Ống kín–một đầu:&nbsp;\u003Cscript type=\"math/tex\">f_n=\\frac{(2n-1)\\,v}{4L},\\quad n=1,2,3,\\dots\u003C/script>\u003C/li>\u003C/ul>\u003Cp>Ứng dụng thực tế gồm kèn ống, sáo, ống cộng hưởng sonar, nơi điều chỉnh chiều dài L để thay đổi tần số phát âm.\u003C/p>\u003Ch2>Sóng điện từ đứng\u003C/h2>\u003Cp>Trong buồng cộng hưởng sóng điện từ (microwave cavity), sóng phản xạ trên thành kim loại tạo ra trường điện từ đứng. Phương trình Maxwell dẫn tới phân bố điện trường E và từ trường B tuân theo:\u003C/p>\u003Cp>\u003Cscript type=\"math/tex\">E(x,t)=E_0\\sin(kx)\\cos(\\omega t),\\quad B(x,t)=B_0\\cos(kx)\\sin(\\omega t)\u003C/script>\u003C/p>\u003Cp>Điều kiện biên kim loại yêu cầu thành buồng là nút điện trường (E=0), từ đó tần số cộng hưởng xác định theo kích thước và hình dạng buồng. Ứng dụng trong lò vi sóng, máy đo dielectrics và thí nghiệm quang học lượng tử.\u003C/p>\u003Ch2>Cộng hưởng và tần số cộng hưởng\u003C/h2>\u003Cp>Cộng hưởng xảy ra khi tần số kích thích trùng với một trong các tần số cộng hưởng fₙ, dẫn đến biên độ dao động cực đại. Độ lợi cộng hưởng thể hiện qua hệ số chất lượng Q:\u003C/p>\u003Cp>\u003Cscript type=\"math/tex\">Q = \\frac{\\omega_0}{\\Delta \\omega}\u003C/script>, với ω₀ là tần số cộng hưởng chính và Δω băng thông tại biên độ giảm √2/2.\u003C/p>\u003Cp>Trong thực tế, hệ số Q cao giúp dao động bền vững lâu nhưng dễ gây quá dao động; Q thấp khắc phục dao động dư, thích hợp cho hệ giảm chấn và thiết bị chống cộng hưởng.\u003C/p>\u003Ch2>Ứng dụng trong kỹ thuật và khoa học\u003C/h2>\u003Cp>Sóng đứng được tận dụng trong thiết kế nhạc cụ dây (đàn guitar, violon), ống thổi (kèn, sáo) và buồng vọng âm thanh. Trong y sinh, sóng siêu âm đứng tạo vùng áp suất thay đổi để đo mật độ mô hoặc phá huỷ tế bào ung thư.\u003C/p>\u003Cp>Trong công nghiệp, cộng hưởng cơ khí dùng để đo vận tốc sóng và xác định mô đun đàn hồi vật liệu thông qua phân tích tần số cộng hưởng. Sóng đứng trong ống và buồng cộng hưởng cũng ứng dụng làm cảm biến áp suất, lưu lượng chất lỏng và khí.\u003C/p>\u003Ch2>Phương pháp đo và quan sát\u003C/h2>\u003Cp>Laser Doppler Vibrometry (LDV) đo biên độ dao động tại nút và bụng sóng trên bề mặt vật thể. Kỹ thuật này không tiếp xúc, cho phép ghi lại modal shapes và tần số cộng hưởng với độ phân giải cao.\u003C/p>\u003Cp>Phần mềm phần tử hữu hạn (FEM) mô phỏng modal analysis để dự đoán vị trí nút–bụng và phổ tần số cộng hưởng. So sánh kết quả số và dữ liệu thực nghiệm qua vibrometer giúp hiệu chỉnh mô hình và vật liệu.\u003C/p>\u003Cul>\u003Cli>Quan sát trực tiếp: gắn cảm biến gia tốc hoặc vi đo rung.\u003C/li>\u003Cli>Hệ thống camera tốc độ cao: ghi ảnh chuyển động của vạch sơn trên dây/ống.\u003C/li>\u003Cli>Phân tích phổ FFT: xác định tần số cộng hưởng từ tín hiệu dao động.\u003C/li>\u003C/ul>\u003Ch2>Tài liệu tham khảo\u003C/h2>\u003Col>\u003Cli>HyperPhysics. “Standing Waves.” Georgia State University. \u003Ca href=\"http://hyperphysics.phy-astr.gsu.edu/hbase/Waves/standing.html\">hyperphysics.phy-astr.gsu.edu\u003C/a>\u003C/li>\u003Cli>Hecht, E. \u003Ci>Optics\u003C/i>. Addison-Wesley, 2002.\u003C/li>\u003Cli>Fletcher, N. H., Rossing, T. D. \u003Ci>The Physics of Musical Instruments\u003C/i>. Springer, 1998.\u003C/li>\u003Cli>Kinsler, L. E., Frey, A. R., Coppens, A. B., Sanders, J. V. \u003Ci>Fundamentals of Acoustics\u003C/i>. Wiley, 2000.\u003C/li>\u003Cli>Sakamoto, S., et al. “Microwave Cavity Resonators: Theory and Applications.” \u003Ci>IEEE Trans. Microw. Theory Techn.\u003C/i>, 2015. \u003Ca href=\"https://ieeexplore.ieee.org/document/7108330\">IEEE Xplore\u003C/a>\u003C/li>\u003C/ol>",{"id":110,"researcherId":24,"name":314,"imageUrl":315},"Nguyễn Ngọc Sơn","https://lh3.googleusercontent.com/a/ACg8ocLGfGsF1nYQqYK5BasTLhNu1dBrBXg2fcEgBNPXJ0p2gqLQnO7i=s96-c",{"id":317,"researcherId":24,"name":318,"imageUrl":319},2681,"Cuong Ta","https://lh3.googleusercontent.com/a/ACg8ocKFuWh0ZD601Hp0_V_2xAK3kIOs20Kyv3V5ZLBo6fwfjyymJYzE=s96-c",[309],"PUBLISHED","2025-07-13T02:19:46.895+00:00","2025-09-10T21:52:33.333+00:00","2025-07-17T09:50:26.537+00:00",48,[327,330,333,336,339,342,345,348,351,354],{"id":328,"title":329},"vọng cách","Vọng cách là gì? Các nghiên cứu khoa học về Vọng cách",{"id":331,"title":332},"đánh giá hiệu suất","Đánh giá hiệu suất là gì? Các nghiên cứu khoa học liên quan",{"id":334,"title":335},"biến dạng","Biến dạng là gì? Các công bố khoa học về Biến dạng",{"id":337,"title":338},"kháng thể tự động","Kháng thể tự động là gì? Các nghiên cứu khoa học liên quan",{"id":340,"title":341},"cắt bỏ khối u","Cắt bỏ khối u là gì? Các bài nghiên cứu khoa học liên quan",{"id":343,"title":344},"bệnh lý mắt graves","Bệnh lý mắt graves là gì? Các nghiên cứu khoa học liên quan",{"id":346,"title":347},"vạt cánh quạt","Vạt cánh quạt là gì? Các bài nghiên cứu khoa học liên quan",{"id":349,"title":350},"hormone cận giáp","Hormone cận giáp là gì? Các nghiên cứu khoa học liên quan",{"id":352,"title":353},"học máy","Học máy là gì? Các bài nghiên cứu khoa học về Học máy",{"id":355,"title":356},"trường vectơ","Trường vectơ là gì? Các bài nghiên cứu khoa học liên quan",{"meta":358,"data":360},{"total":359},"668",[361,1077,1418,1901,2077,3623,3866,4111,4537,5196],{"id":362,"createTime":363,"updateTime":364,"relativeEntities":365,"slug":366,"properties":367,"entityType":20,"verifyStatus":384,"verifyTime":363,"verifyNote":385,"syncStatus":386,"languages":387,"translateLanguages":389,"viewCount":25,"primaryUrl":391,"fullTextUrl":24,"authors":392,"publicationType":22,"publisherRelationship":787,"citationCount":952,"citationInfo":953,"publishDate":967,"publishYear":968,"citationAnalyzeStatus":386,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":969,"isForceReanalyzing":26},"9b7a8356-222e-46dc-95be-f551c4551a4f","2024-11-25T11:37:56.715+00:00","2024-12-25T15:43:17.317+00:00",[],"Phase-III-Study-of-Afatinib-or-Cisplatin-Plus-Pemetrexed-in-Patients-With-Metastatic-Lung-Adenocarcinoma-With-i-EGFR-i-Mutations",{"mag":368,"keywords":370,"openalex":372,"abstract":374,"title":377,"pm":380,"doi":382},{"VOID":369},"2096198395",{"VI":371},"Afatinib, cisplatin, pemetrexed, adenocarcinoma phổi, đột biến EGFR, sống không tiến triển, hóa trị, giảm đau, kiểm soát triệu chứng, đột biến exon 19, L858R, tác dụng phụ, nghiên cứu lâm sàng giai đoạn III",{"VOID":373},"W2096198395",{"EN":375,"VI":376},"\u003Cjats:sec>\u003Cjats:title>Purpose\u003C/jats:title>\u003Cjats:p> The LUX-Lung 3 study investigated the efficacy of chemotherapy compared with afatinib, a selective, orally bioavailable ErbB family blocker that irreversibly blocks signaling from epidermal growth factor receptor (EGFR/ErbB1), human epidermal growth factor receptor 2 (HER2/ErbB2), and ErbB4 and has wide-spectrum preclinical activity against EGFR mutations. A phase II study of afatinib in EGFR mutation–positive lung adenocarcinoma demonstrated high response rates and progression-free survival (PFS). \u003C/jats:p>\u003C/jats:sec>\u003Cjats:sec>\u003Cjats:title>Patients and Methods\u003C/jats:title>\u003Cjats:p> In this phase III study, eligible patients with stage IIIB/IV lung adenocarcinoma were screened for EGFR mutations. Mutation-positive patients were stratified by mutation type (exon 19 deletion, L858R, or other) and race (Asian or non-Asian) before two-to-one random assignment to 40 mg afatinib per day or up to six cycles of cisplatin plus pemetrexed chemotherapy at standard doses every 21 days. The primary end point was PFS by independent review. Secondary end points included tumor response, overall survival, adverse events, and patient-reported outcomes (PROs). \u003C/jats:p>\u003C/jats:sec>\u003Cjats:sec>\u003Cjats:title>Results\u003C/jats:title>\u003Cjats:p> A total of 1,269 patients were screened, and 345 were randomly assigned to treatment. Median PFS was 11.1 months for afatinib and 6.9 months for chemotherapy (hazard ratio [HR], 0.58; 95% CI, 0.43 to 0.78; P = .001). Median PFS among those with exon 19 deletions and L858R EGFR mutations (n = 308) was 13.6 months for afatinib and 6.9 months for chemotherapy (HR, 0.47; 95% CI, 0.34 to 0.65; P = .001). The most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis for afatinib and nausea, fatigue, and decreased appetite for chemotherapy. PROs favored afatinib, with better control of cough, dyspnea, and pain. \u003C/jats:p>\u003C/jats:sec>\u003Cjats:sec>\u003Cjats:title>Conclusion\u003C/jats:title>\u003Cjats:p> Afatinib is associated with prolongation of PFS when compared with standard doublet chemotherapy in patients with advanced lung adenocarcinoma and EGFR mutations. \u003C/jats:p>\u003C/jats:sec>","\u003Cjats:sec>\u003Cjats:title>Mục tiêu\u003C/jats:title>\u003Cjats:p>Nghiên cứu LUX-Lung 3 đã khảo sát hiệu quả của hóa trị so với afatinib, một chất ức chế có khả năng phong tỏa tín hiệu không hồi phục từ thụ thể yếu tố tăng trưởng biểu bì (EGFR/ErbB1), thụ thể 2 (HER2/ErbB2) và ErbB4. Afatinib cho thấy khả năng hoạt động rộng rãi đối với các đột biến EGFR. Nghiên cứu giai đoạn II về afatinib ở ung thư tuyến phổi với đột biến EGFR đã thể hiện tỷ lệ đáp ứng cao và sống không tiến triển (PFS). \u003C/jats:p>\u003C/jats:sec>\u003Cjats:sec>\u003Cjats:title>Đối tượng và phương pháp\u003C/jats:title>\u003Cjats:p>Trong nghiên cứu giai đoạn III này, các bệnh nhân ung thư phổi giai đoạn IIIB/IV đủ điều kiện đã được sàng lọc đột biến EGFR. Các bệnh nhân có đột biến được phân tầng theo loại đột biến (xóa exon 19, L858R, hoặc các dạng khác) và chủng tộc (người Châu Á hoặc không Châu Á) trước khi phân ngẫu nhiên theo tỷ lệ 2:1 để nhận 40 mg afatinib mỗi ngày hoặc tối đa sáu chu kỳ hóa trị bằng cisplatin và pemetrexed với liều chuẩn mỗi 21 ngày. Điểm cuối chính là PFS được đánh giá độc lập. Các điểm cuối phụ bao gồm phản ứng khối u, sống còn tổng thể, tác dụng phụ và kết quả do bệnh nhân báo cáo. \u003C/jats:p>\u003C/jats:sec>\u003Cjats:sec>\u003Cjats:title>Kết quả\u003C/jats:title>\u003Cjats:p>Tổng cộng 1269 bệnh nhân đã được sàng lọc và 345 người được phân ngẫu nhiên vào điều trị. Thời gian PFS trung bình là 11,1 tháng đối với afatinib và 6,9 tháng đối với hóa trị (tỷ lệ nguy cơ (HR), 0.58; 95% CI, 0.43 đến 0.78; P = .001). Trong những bệnh nhân có đột biến xóa exon 19 và L858R EGFR (n = 308), thời gian PFS trung bình là 13,6 tháng đối với afatinib và 6,9 tháng đối với hóa trị (HR, 0.47; 95% CI, 0.34 đến 0.65; P = .001). Các tác dụng phụ phổ biến nhất liên quan đến điều trị là tiêu chảy, phát ban/mụn trứng cá, và viêm miệng cho afatinib và buồn nôn, mệt mỏi, và chán ăn cho hóa trị. Kết quả do bệnh nhân báo cáo thiên về afatinib, với khả năng kiểm soát tốt hơn về ho, khó thở, và đau. \u003C/jats:p>\u003C/jats:sec>\u003Cjats:sec>\u003Cjats:title>Kết luận\u003C/jats:title>\u003Cjats:p>Afatinib liên quan đến việc kéo dài thời gian sống không tiến triển khi so sánh với hóa trị tiêu chuẩn kép ở bệnh nhân ung thư phổi tuyến di căn với đột biến EGFR. \u003C/jats:p>\u003C/jats:sec>",{"EN":378,"VI":379},"Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With \u003Ci>EGFR\u003C/i> Mutations","Nghiên cứu giai đoạn III về Afatinib hoặc Cisplatin kết hợp Pemetrexed ở bệnh nhân ung thư tuyến phổi di căn với đột biến EGFR",{"VOID":381},"23816960",{"VOID":383},"10.1200/jco.2012.44.2806","VERIFIED","Auto Verify","PENDING",[388],"EN",[390],"VI","https://ascopubs.org/doi/10.1200/JCO.2012.44.2806",[393,412,430,458,475,493,520,538,555,573,595,617,635,653,671,688,705,723,751,769],{"id":394,"sortIndex":145,"researcher":24,"roles":395,"affiliations":396,"properties":407},"926c40e5-45c2-47d4-900b-c515fcce6558",[],[397],{"id":398,"sortIndex":25,"affiliation":399,"properties":24},"90581c5f-f937-40c7-8cd6-9cc978d4d18c",{"id":400,"createTime":401,"updateTime":401,"relativeEntities":402,"slug":403,"properties":404,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"ea6fa6b8-ae0d-4b75-a2c1-fef3f47ada2e","2024-11-25T11:37:56.733+00:00",[],"Lecia-V-Sequist-Massachusetts-General-Hospital-and-Harvard-Medical-School-Boston-MA-James-Chih-Hsin-Yang-National-Taiwan-University-Hospital-Chun-Ming-Tsai-Taipei-Veterans-General-Hospital-Taipei-Wu-Chou-Su-National-Cheng-Kung-University-Hospital-Tainan-Taiwan-Nobuyuki-Yamamoto-Shizuoka-Cancer-Center-Shizuoka-Terufumi-Kato-Kanagawa-Cardiovascular-and-Respiratory-Center-Yokohama-Japan-Kenneth-O-Byrne-St-James-Hospital-Dublin-Ireland-Vera-Hirsh-McGill-University-Montreal-Quebec-",{"title":405},{"EN":406},"Lecia V. 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Urban sprawl and public health: designing, planning, and building for healthy communities. Washington, DC, USA: Island Press, 2004.",{},{"id":24,"text":1318,"url":24,"identifiers":1319},"10.1016/S0749-3797(02)00475-0",{"doi":1318},{"id":24,"text":1321,"url":24,"identifiers":1322},"10.1207/S15324796ABM2502_03",{"doi":1321},{"id":24,"text":1324,"url":24,"identifiers":1325},"10.1016/j.trd.2005.04.001",{"doi":1324},{"id":24,"text":1327,"url":24,"identifiers":1328},"Sallis, 2004, Active transportation and physical activity: opportunities for collaboration on transportation and public health research, Transport Res A, 38, 249",{},{"id":24,"text":1330,"url":24,"identifiers":1331},"Transporation Research Board – Institute of Medicine. Does the built environment influence physical activity? Examining the evidence. 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Health and community design: the impact of the built environment on physical activity. Washington, DC, USA: Island Press, 2003.",{},{"id":24,"text":1361,"url":24,"identifiers":1362},"Lavizzo-Mourey, 2003, Making the case for active living communities, Am J Pub Health, 93, 1386, 10.2105/AJPH.93.9.1386",{"doi":1363},"10.2105/AJPH.93.9.1386",{"id":24,"text":1365,"url":24,"identifiers":1366},"10.2105/AJPH.93.9.1446",{"doi":1365},{"id":24,"text":1368,"url":24,"identifiers":1369},"10.1177/08854120022092890",{"doi":1368},{"id":24,"text":1371,"url":24,"identifiers":1372},"10.4278/0890-1171-18.1.21",{"doi":1371},{"id":24,"text":1374,"url":24,"identifiers":1375},"10.2105/AJPH.93.9.1478",{"doi":1374},{"id":24,"text":1377,"url":24,"identifiers":1378},"10.1016/S1361-9209(97)00009-6",{"doi":1377},{"id":24,"text":1380,"url":24,"identifiers":1381},"10.1177/0739456X02250315",{"doi":1380},{"id":24,"text":1383,"url":24,"identifiers":1384},"10.1177/0739456X04267714",{"doi":1383},{"id":24,"text":1386,"url":24,"identifiers":1387},"Sallis JF Owen N . Physical activity and behavioral medicine. Thousand Oaks, California, USA: Sage, 1999.",{},{"id":24,"text":1389,"url":24,"identifiers":1390},"Sallis JF Owen N . Ecological models of health behavior. In: Glanz K Rimer BK Lewis FM , eds. Health behavior and health education: theory, research, and practice, 3rd edn. San Francisco, California, USA: Jossey-Bass, 2002: 462–84",{},{"id":24,"text":1392,"url":24,"identifiers":1393},"10.1016/j.socscimed.2009.01.017",{"doi":1392},{"id":24,"text":1395,"url":24,"identifiers":1396},"Vuchic VR . Transportation for livable cities. Newark, New Jersey., USA: CUPR – Center for Urban Policy Research, Rutgers University, 1999.",{},{"id":24,"text":1398,"url":24,"identifiers":1399},"10.3141/1578-07",{"doi":1398},{"id":24,"text":1401,"url":24,"identifiers":1402},"Bureau of Transportation Statistics and Federal Highway Administration. National household travel survey: preliminary release, 2003. Washington, DC, USA: US Department of Transportation, 2003.",{},{"id":24,"text":1404,"url":24,"identifiers":1405},"10.1016/j.ypmed.2008.04.004",{"doi":1404},{"id":24,"text":1407,"url":24,"identifiers":1408},"10.1136/bjsm.2008.055533",{"doi":1407},{"id":24,"text":1410,"url":24,"identifiers":1411},"US Department of Health and Human Services. Healthy people 2010. No. 017-001-00547-9. Washington, DC, USA: US Department of Health and Human Services, 2000.",{},{"id":24,"text":1413,"url":24,"identifiers":1414},"World Health Organization. The world health report 2002. Geneva, Switzerland: World Health Organization, 2002.",{},{"id":24,"text":1416,"url":24,"identifiers":1417},"10.1016/j.amepre.2004.10.032",{"doi":1416},{"id":1419,"createTime":1420,"updateTime":1421,"relativeEntities":1422,"slug":1423,"properties":1424,"entityType":20,"verifyStatus":384,"verifyTime":1420,"verifyNote":385,"syncStatus":386,"languages":1443,"translateLanguages":1444,"viewCount":25,"primaryUrl":1445,"fullTextUrl":24,"authors":1446,"publicationType":22,"publisherRelationship":1708,"citationCount":1757,"citationInfo":1758,"publishDate":1765,"publishYear":1766,"citationAnalyzeStatus":386,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":1767,"isForceReanalyzing":26},"24079142-8be0-446b-a669-803f03c32a5d","2024-10-16T16:39:11.089+00:00","2024-12-24T21:27:38.919+00:00",[],"Long-term-findings-from-COMFORT-II-a-phase-3-study-of-ruxolitinib-vs-best-available-therapy-for-myelofibrosis",{"mag":1425,"keywords":1427,"pmc":1429,"openalex":1431,"abstract":1433,"title":1436,"pm":1439,"doi":1441},{"VOID":1426},"2405712018",{"VI":1428},"ruxolitinib, Janus kinase ức chế, xơ tủy, COMFORT-II, khối lượng lách, tỷ lệ sống còn, phân tích giai đoạn 3, nguy cơ tử vong, tác dụng phụ",{"VOID":1430},"7609269",{"VOID":1432},"W2405712018",{"EN":1434,"VI":1435},"\u003Cjats:title>Abstract\u003C/jats:title>\n \u003Cjats:p>Ruxolitinib is a Janus kinase (JAK) (JAK1/JAK2) inhibitor that has demonstrated superiority over placebo and best available therapy (BAT) in the Controlled Myelofibrosis Study with Oral JAK Inhibitor Treatment (COMFORT) studies. COMFORT-II was a randomized (2:1), open-label phase 3 study in patients with myelofibrosis; patients randomized to BAT could crossover to ruxolitinib upon protocol-defined disease progression or after the primary end point, confounding long-term comparisons. At week 48, 28% (41/146) of patients randomized to ruxolitinib achieved ⩾35% decrease in spleen volume (primary end point) compared with no patients on BAT (\u003Cjats:italic>P\u003C/jats:italic>&lt;0.001). Among the 78 patients (53.4%) in the ruxolitinib arm who achieved ⩾35% reductions in spleen volume at any time, the probability of maintaining response was 0.48 (95% confidence interval (CI), 0.35–0.60) at 5 years (median, 3.2 years). Median overall survival was not reached in the ruxolitinib arm and was 4.1 years in the BAT arm. There was a 33% reduction in risk of death with ruxolitinib compared with BAT by intent-to-treat analysis (hazard ratio (HR)=0.67; 95% CI, 0.44–1.02; \u003Cjats:italic>P\u003C/jats:italic>=0.06); the crossover-corrected HR was 0.44 (95% CI, 0.18–1.04; \u003Cjats:italic>P\u003C/jats:italic>=0.06). There was no unexpected increased incidence of adverse events with longer exposure. This final analysis showed that spleen volume reductions with ruxolitinib were maintained with continued therapy and may be associated with survival benefits.\u003C/jats:p>","\u003Ctitle>Tóm tắt\u003C/title> \u003Cp>Ruxolitinib là một chất ức chế Janus kinase (JAK) (JAK1/JAK2) đã cho thấy sự vượt trội hơn so với giả dược và liệu pháp tốt nhất có sẵn (BAT) trong các nghiên cứu Controlled Myelofibrosis Study với điều trị bằng thuốc uống ức chế JAK (COMFORT). COMFORT-II là một nghiên cứu pha 3 ngẫu nhiên (2:1), mở tại những bệnh nhân bị xơ tủy; những bệnh nhân được phân ngẫu nhiên vào nhóm BAT có thể chuyển sang ruxolitinib khi bệnh tiến triển theo định nghĩa của giao thức hoặc sau kết thúc điểm chính, làm phức tạp so sánh dài hạn. Vào tuần thứ 48, 28% (41/146) bệnh nhân được phân ngẫu nhiên vào ruxolitinib đạt được giảm ⩾35% khối lượng lách (điểm chính) so với không có bệnh nhân nào ở BAT (\u003Citalic>P\u003C/italic>&lt;0.001). Trong số 78 bệnh nhân (53.4%) trong nhánh ruxolitinib đạt được giảm ⩾35% khối lượng lách bất kỳ lúc nào, xác suất duy trì đáp ứng là 0.48 (khoảng tin cậy (CI), 0.35–0.60) sau 5 năm (trung vị, 3.2 năm). Trung vị thời gian sống toàn bộ chưa được đạt ở nhánh ruxolitinib và là 4.1 năm ở nhánh BAT. Có giảm 33% nguy cơ tử vong với ruxolitinib so với BAT theo phân tích ý định điều trị (tỷ lệ nguy cơ (HR) = 0.67; CI 95%, 0.44–1.02; \u003Citalic>P\u003C/italic> = 0.06); HR điều chỉnh chéo là 0.44 (CI 95%, 0.18–1.04; \u003Citalic>P\u003C/italic> = 0.06). Không có sự gia tăng không mong đợi về tỷ lệ mắc phải tác dụng phụ với thời gian dùng lâu hơn. Phân tích cuối cùng này cho thấy rằng các giảm khối lượng lách với ruxolitinib được duy trì với liệu pháp tiếp tục và có thể liên quan đến lợi ích sống còn.\u003C/p>",{"EN":1437,"VI":1438},"Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis","Kết quả dài hạn từ nghiên cứu COMFORT-II, thử nghiệm giai đoạn 3 của ruxolitinib so với liệu pháp tốt nhất có sẵn cho bệnh xơ 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France",{"openalex":1506,"orcid":1508,"title":1510},{"VOID":1507},"A5008609620",{"VOID":1509},"https://orcid.org/0000-0002-8121-438X",{"EN":1511},"Jean‐Jacques Kiladjian",{"id":1513,"sortIndex":145,"researcher":24,"roles":1514,"affiliations":1515,"properties":1527},"1e1d771c-4368-4bff-b543-aa3c92924022",[],[1516],{"id":1517,"sortIndex":25,"affiliation":1518,"properties":24},"0c1d721e-4d6b-4864-909b-719295b83e5e",{"id":1519,"createTime":1520,"updateTime":1521,"relativeEntities":1522,"slug":1523,"properties":1524,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"41c6960b-fff5-46eb-939b-08f77224477e","2024-01-10T05:18:13.210+00:00","2024-12-26T18:10:19.989+00:00",[],"Medical-University-of-Vienna-Vienna-Austria",{"title":1525},{"VI":1526},"Medical University of Vienna, Vienna, Austria",{"openalex":1528,"orcid":1530,"title":1532},{"VOID":1529},"A5049331182",{"VOID":1531},"https://orcid.org/0000-0002-0295-7629",{"EN":1533},"Heinz Gisslinger",{"id":1535,"sortIndex":134,"researcher":24,"roles":1536,"affiliations":1537,"properties":1549},"6c2a00e4-d3a9-481b-8c14-87d5f0923a2a",[],[1538],{"id":1539,"sortIndex":25,"affiliation":1540,"properties":24},"1657b559-17dc-4de5-a1b3-cf2d3093b5c4",{"id":1541,"createTime":1542,"updateTime":1543,"relativeEntities":1544,"slug":1545,"properties":1546,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"67e98edc-df52-4829-9d4c-00e1a7fc0161","2024-04-20T16:00:00.874+00:00","2025-01-24T05:09:30.419+00:00",[],"University-of-Leipzig-Leipzig-Germany",{"title":1547},{"EN":1548},"University of Leipzig, Leipzig, 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Management of myelofibrosis. Hematol Am Soc Hematol Educ Program 2011; 2011: 222–230.",{"doi":1771},"10.1182/asheducation-2011.1.222",{"id":24,"text":1773,"url":24,"identifiers":1774},"Vainchenker W, Delhommeau F, Constantinescu SN, Bernard OA . New mutations and pathogenesis of myeloproliferative neoplasms. Blood 2011; 188: 1723–1735.",{"doi":1775},"10.1182/blood-2011-02-292102",{"id":24,"text":1777,"url":24,"identifiers":1778},"Abdel-Wahab O, Pardanani A, Rampal R, Lasho TL, Levine RL, Tefferi A . DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia 2011; 25: 1219–1220.",{"doi":1779},"10.1038/leu.2011.82",{"id":24,"text":1781,"url":24,"identifiers":1782},"Mesa RA, Schwager S, Radia D, Cheville A, Hussein K, Niblack J et al. The Myelofibrosis Symptom Assessment Form (MFSAF): an evidence-based brief inventory to measure quality of life and symptomatic response to treatment in myelofibrosis. Leuk Res 2009; 33: 1199–1203.",{"doi":1783},"10.1016/j.leukres.2009.01.035",{"id":24,"text":1785,"url":24,"identifiers":1786},"Cervantes F, Dupriez B, Pereira A, PassamontiF, Reilly JT, Morra E et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood 2009; 113: 2895–2901.",{"doi":1787},"10.1182/blood-2008-07-170449",{"id":24,"text":1789,"url":24,"identifiers":1790},"Passamonti F, Cervantes F, Vannucchi AM, Morra E, Rumi E, Pereira et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood 2010; 115: 1703–1708.",{"doi":1791},"10.1182/blood-2009-09-245837",{"id":24,"text":1793,"url":24,"identifiers":1794},"Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010; 115: 3109–3117.",{"doi":1795},"10.1182/blood-2009-04-214957",{"id":24,"text":1797,"url":24,"identifiers":1798},"Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012; 366: 787–798.",{"doi":1799},"10.1056/NEJMoa1110556",{"id":24,"text":1801,"url":24,"identifiers":1802},"Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012; 366: 799–807.",{"doi":1803},"10.1056/NEJMoa1110557",{"id":24,"text":1805,"url":24,"identifiers":1806},"Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF et al. Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I. Haematologica 2013; 98: 1865–1871.",{"doi":1807},"10.3324/haematol.2013.092155",{"id":24,"text":1809,"url":24,"identifiers":1810},"Passamonti F, Maffioli M, Cervantes F, Vannucchi AM, Morra E, Barbui T et al. Impact of ruxolitinib on the natural history of primary myelofibrosis: a comparison of the DIPSS and the COMFORT-2 cohorts. Blood 2014; 123: 1833–1835.",{"doi":1811},"10.1182/blood-2013-12-544411",{"id":24,"text":1813,"url":24,"identifiers":1814},"Verstovsek S, Kantarjian HM, Estrov Z, Cortes JE, Thomas DA, Kadia T et al. Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls. Blood 2012; 120: 1202–1209.",{"doi":1815},"10.1182/blood-2012-02-414631",{"id":24,"text":1817,"url":24,"identifiers":1818},"Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF et al. Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I. Haematologica 2015; 100: 479–488.",{"doi":1819},"10.3324/haematol.2014.115840",{"id":24,"text":1821,"url":24,"identifiers":1822},"Cervantes F, Vannucchi AM, Kiladjian JJ, Al-Ali HK, Sirulnik A, Stalbovskaya V et al. Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis. Blood 2013; 122: 4047–4053.",{"doi":1823},"10.1182/blood-2013-02-485888",{"id":24,"text":1825,"url":24,"identifiers":1826},"Robins JM, Tsiatis AA . Correcting for noncompliance in randomized trials using rank preserving structural failure time models. 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Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 2008; 22: 14–22.",{"doi":1839},"10.1038/sj.leu.2404955",{"id":24,"text":1841,"url":24,"identifiers":1842},"Levine RL, Belisle C, Wadleigh M, Zahrieh D, Lee S, Chagnon P et al. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood 2006; 107: 4139–4141.",{"doi":1843},"10.1182/blood-2005-09-3900",{"id":24,"text":1845,"url":24,"identifiers":1846},"Thiele J, Kvasnicka HM, Facchetti F, Franco V, van der Walt J, Orazi A . European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica 2005; 90: 1128–1132.",{},{"id":24,"text":1848,"url":24,"identifiers":1849},"Cervantes F, Kiladjian JJ, Niederwieser D, Sirulnik A, Stalbovskaya V, McQuitty M et al. Long-term efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for the treatment of myelofibrosis. Blood 2012; 120: abstract 801.",{"doi":1850},"10.1182/blood.V120.21.801.801",{"id":24,"text":1852,"url":24,"identifiers":1853},"Deininger M, Radich J, Burn TC, Huber R, Paranagama D, Verstovsek S . The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis. Blood 2015; 126: 1551–1554.",{"doi":1854},"10.1182/blood-2015-03-635235",{"id":24,"text":1856,"url":24,"identifiers":1857},"Wilkins BS, Radia D, Woodley C, Farhi SE, Keohane C, Harrison CN . Resolution of bone marrow fibrosis in a patient receiving JAK1/JAK2 inhibitor treatment with ruxolitinib. Haematologica 2013; 98: 1872–1876.",{"doi":1858},"10.3324/haematol.2013.095109",{"id":24,"text":1860,"url":24,"identifiers":1861},"Kvasnicka HM, Thiele J, Bueso-Ramos CE, Sun W, Cortes J, Kantarjian HM et al. Changes in bone marrow morphology in patients with myelofibrosis treated for up to 5 years with either ruxolitinib or best available therapy. Haematologica 2014; 99 (Suppl 1): 127 (abstract P405).",{},{"id":24,"text":1863,"url":24,"identifiers":1864},"Vannucchi AM, Kantarjian HM, Kiladjian JJ, Gotlib J, Cervantes F, Mesa RA et al. A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase 3 trials of ruxolitinib for the treatment of myelofibrosis. Haematologica 2015; 100: 1139–1145.",{"doi":1865},"10.3324/haematol.2014.119545",{"id":24,"text":1867,"url":24,"identifiers":1868},"Al-Ali HK, Stalbovskaya V, Gopalakrishna P, Perez Ronco J, Foltz LM . Ruxolitinib overcomes the adverse prognostic effect of anemia in patients with myelofibrosis. Blood 2014; 124: abstract 4583.",{"doi":1869},"10.1182/blood.V124.21.4583.4583",{"id":24,"text":1871,"url":24,"identifiers":1872},"Polverelli N, Breccia M, Benevolo G, Martino B, Tieghi A, Latagliata R et al. Risk factors for infections in myelofibrosis: role of disease status and treatment. A study on 507 patients. Blood 2015; 126: abstract 1606.",{"doi":1873},"10.1182/blood.V126.23.1606.1606",{"id":24,"text":1875,"url":24,"identifiers":1876},"Hultcrantz M, Lund SH, Andersson TM, Björkholm M, Kristinsson S . Myeloproliferative neoplasms and infections; a population-based study on 9,665 patients with myeloproliferative neoplasms diagnosed in Sweden 1987-2009. Haematologica 2015; 100 (Suppl 1): 260 (abstract P666).",{},{"id":24,"text":1878,"url":24,"identifiers":1879},"Tefferi A, Rumi E, Finazzi G, Gisslinger H, Vannucchi AM, Rodeghiero F et al. Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study. 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Leukemia 2015; 29: 20–26.",{"doi":1900},"10.1038/leu.2014.250",{"id":1902,"createTime":1903,"updateTime":1904,"relativeEntities":1905,"slug":1906,"properties":1907,"entityType":20,"verifyStatus":384,"verifyTime":1903,"verifyNote":385,"syncStatus":386,"languages":1924,"translateLanguages":1925,"viewCount":25,"primaryUrl":1926,"fullTextUrl":24,"authors":1927,"publicationType":22,"publisherRelationship":1947,"citationCount":2066,"citationInfo":2067,"publishDate":2074,"publishYear":2075,"citationAnalyzeStatus":386,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":2076,"isForceReanalyzing":26},"364e6298-dba7-4a7d-a367-84a524245db4","2024-09-17T16:31:30.565+00:00","2024-12-26T09:04:17.258+00:00",[],"ClustalW-MPI-ClustalW-analysis-using-distributed-and-parallel-computing",{"mag":1908,"keywords":1910,"openalex":1912,"abstract":1914,"title":1917,"pm":1920,"doi":1922},{"VOID":1909},"2155518645",{"VI":1911},"ClustalW, căn chỉnh chuỗi, tính toán phân tán, tính toán song song, MPI, protein, nucleotide",{"VOID":1913},"W2155518645",{"EN":1915,"VI":1916},"\u003Cjats:title>Abstract\u003C/jats:title>\n \u003Cjats:p>Summary: ClustalW is a tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three steps: pairwise alignment, guide-tree generation and progressive alignment. ClustalW-MPI is a distributed and parallel implementation of ClustalW. All three steps have been parallelized to reduce the execution time. The software uses a message-passing library called MPI (Message Passing Interface) and runs on distributed workstation clusters as well as on traditional parallel computers.\u003C/jats:p>\n \u003Cjats:p>Availability:The source codes are written in ISO C and are available at http://www.bii.a-star.edu.sg/software/clustalw-mpi/. An open source implementations of MPI http://www-unix.mcs.anl.gov/mpi/.\u003C/jats:p>\n \u003Cjats:p>Contact: kuobin@bii.a-star.edu.sg\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title> \u003Cjats:p>Tóm lược: ClustalW là một công cụ để căn chỉnh nhiều chuỗi protein hoặc nucleotide. Việc căn chỉnh này được thực hiện thông qua ba bước: căn chỉnh từng cặp, tạo cây hướng dẫn và căn chỉnh tiến dần. ClustalW-MPI là một triển khai phân tán và song song của ClustalW. Cả ba bước đều đã được thực hiện song song để giảm thời gian thực hiện. Phần mềm sử dụng một thư viện truyền thông điệp gọi là MPI (Giao diện Truyền thông Điệp) và chạy trên các cụm máy trạm phân tán cũng như trên các máy tính song song truyền thống.\u003C/jats:p> \u003Cjats:p>Khả dụng: Mã nguồn được viết bằng ISO C và có tại http://www.bii.a-star.edu.sg/software/clustalw-mpi/. Một triển khai mã nguồn mở của MPI có tại http://www-unix.mcs.anl.gov/mpi/.\u003C/jats:p> \u003Cjats:p>Liên hệ: kuobin@bii.a-star.edu.sg\u003C/jats:p>",{"EN":1918,"VI":1919},"ClustalW-MPI: ClustalW analysis using distributed and parallel computing","ClustalW-MPI: Phân tích ClustalW sử dụng tính toán phân tán và song song",{"VOID":1921},"12912844",{"VOID":1923},"10.1093/bioinformatics/btg192",[388],[390],"https://academic.oup.com/bioinformatics/article/19/12/1585/257936",[1928],{"id":1929,"sortIndex":25,"researcher":24,"roles":1930,"affiliations":1931,"properties":1942},"d2627329-a647-4358-b7b1-773b8600e429",[],[1932],{"id":1933,"sortIndex":25,"affiliation":1934,"properties":24},"d09b70a9-939a-4e02-8935-3a973f512103",{"id":1935,"createTime":1936,"updateTime":1936,"relativeEntities":1937,"slug":1938,"properties":1939,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"de995b77-66aa-45fb-8267-34b872102ed4","2024-09-17T16:31:30.576+00:00",[],"Bioinformatics-Institute-30-Medical-Drive-Singapore-117609-Republic-of-Singapore",{"title":1940},{"EN":1941},"Bioinformatics Institute, \r\n30 Medical Drive, Singapore 117609, Republic of Singapore",{"openalex":1943,"title":1945},{"VOID":1944},"A5043612988",{"EN":1946},"Kuo-Bin Li",{"url":24,"publisher":1948,"properties":2059},{"id":1949,"createTime":1950,"updateTime":1951,"relativeEntities":1952,"slug":1953,"properties":1954,"entityType":264,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":1963,"manageAffiliations":1964,"indexDatabases":1965,"url":1994,"thumbnailPath":24,"statistic":1995,"gsStatistic":24,"type":24,"analyzePriority":24},"6624d7c2-f227-440b-b1ed-9ff88a3948fe","2023-05-29T10:28:09.117+00:00","2025-01-26T03:59:42.712+00:00",[],"Bioinformatics",{"country":1955,"issn":1956,"introduce":1958,"eissn":1960,"title":1962},{"VOID":1248},{"VOID":1957},"13674803",{"EN":1959},"The leading journal in its field, Bioinformatics publishes the highest quality scientific papers and review articles of interest to academic and industrial researchers. Its main focus is on new developments in genome bioinformatics and computational biology. 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chất ba oxit khoáng, xi măng nội nha sinh học, liệu pháp tủy sống, nội nha tái tạo, sửa chữa lỗ thủng, tác dụng không mong muốn.",{"VOID":2089},"W2747159220",{"EN":2091,"VI":2092},"\u003Cjats:title>Abstract\u003C/jats:title>\u003Cjats:p>Mineral trioxide aggregate (MTA) is a dental material used extensively for vital pulp therapies (VPT), protecting scaffolds during regenerative endodontic procedures, apical barriers in teeth with necrotic pulps and open apices, perforation repairs as well as root canal filling and root‐end filling during surgical endodontics. A number of bioactive endodontic cements (BECs) have recently been introduced to the market. Most of these materials have calcium and silicate in their compositions; however, bioactivity is a common property of these cements. These materials include the following: BioAggregate, Biodentine, BioRoot RCS, calcium‐enriched mixture cement, Endo‐CPM, Endocem, EndoSequence, EndoBinder, EndoSeal MTA, iRoot, MicroMega MTA, MTA Bio, MTA Fillapex, MTA Plus, Neo MTA Plus, Ortho MTA, Quick‐Set, Retro MTA, Tech Biosealer, and TheraCal LC. It has been claimed that these materials have properties similar to those of MTA but without the drawbacks. In Part I of this review, the available information on the chemical composition of the materials listed above was reviewed and their applications for VPT was discussed. In this article, the clinical applications of MTA and other BECs will be reviewed for apexification, regenerative endodontics, perforation repair, root canal filling, root‐end filling, restorative procedures, periodontal defects and treatment of vertical and horizontal root fractures. In addition, the literature regarding the possible drawbacks of these materials following their clinical applications is reviewed. These drawbacks include their discolouration potential, systemic effects and retreatability following use as a root filling material. Based on selected keywords, all publications were searched regarding the use of MTA as well as BECs for the relevant clinical applications. Numerous publications were found regarding the use of BECs for various endodontic applications. The majority of these investigations compared BECs with MTA. Despite promising results for some materials, the number of publications using BECs for various clinical applications was limited. Furthermore, most studies had several methodological shortcomings and low levels of evidence.\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title>\u003Cjats:p>Hợp chất ba oxit khoáng (MTA) là vật liệu nha khoa được sử dụng rộng rãi cho các liệu pháp tủy sống (VPT), bảo vệ các giá đỡ trong các quy trình nội nha tái tạo, tạo rào cản ở các răng có tủy hoại tử và chóp mở, sửa chữa các lỗ thủng cũng như trám bít ống tủy và trám bít chóp răng trong các phẫu thuật nội nha. Gần đây, một số xi măng nội nha sinh học (BECs) đã được giới thiệu trên thị trường. Hầu hết những vật liệu này có thành phần bao gồm canxi và silicat; tuy nhiên, tính sinh học tích cực là đặc tính chung của các xi măng này. Các vật liệu này bao gồm: BioAggregate, Biodentine, BioRoot RCS, xi măng hỗn hợp giàu canxi, Endo-CPM, Endocem, EndoSequence, EndoBinder, EndoSeal MTA, iRoot, MicroMega MTA, MTA Bio, MTA Fillapex, MTA Plus, Neo MTA Plus, Ortho MTA, Quick-Set, Retro MTA, Tech Biosealer, và TheraCal LC. Đã có những tuyên bố rằng các vật liệu này có các đặc tính tương tự như MTA nhưng không có những hạn chế. Ở Phần I của bài đánh giá này, thông tin hiện có về thành phần hóa học của các vật liệu nêu trên đã được xem xét và ứng dụng của chúng cho VPT đã được thảo luận. Trong bài viết này, các ứng dụng lâm sàng của MTA và các BEC khác sẽ được xem xét cho việc tạo chóp, nội nha tái tạo, sửa chữa lỗ thủng, trám bít ống tủy, trám bít chóp răng, các quy trình phục hồi, khuyết tật nha chu và điều trị gãy răng theo chiều dọc và ngang. Ngoài ra, tài liệu liên quan đến những hạn chế có thể xảy ra của các vật liệu này sau khi ứng dụng lâm sàng được xem xét. Những hạn chế này bao gồm khả năng đổi màu, tác động toàn thân và khả năng rút lui sau khi sử dụng làm vật liệu trám bít ống tủy. Dựa trên các từ khóa đã chọn, tất cả các công bố đã được tìm kiếm liên quan đến việc sử dụng MTA cũng như BECs cho các ứng dụng lâm sàng liên quan. Nhiều công bố đã được tìm thấy liên quan đến việc sử dụng BEC cho các ứng dụng nội nha khác nhau. Đa số các nghiên cứu này so sánh BEC với MTA. Mặc dù có kết quả đầy hứa hẹn đối với một số vật liệu, số lượng công bố sử dụng BEC cho các ứng dụng lâm sàng khác nhau là hạn chế. Hơn nữa, hầu hết các nghiên cứu đều có một số khiếm khuyết phương pháp luận và bằng chứng thấp.",{"EN":2094,"VI":2095},"Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications","Hợp chất ba oxit khoáng và các xi măng nội nha sinh học khác: tổng quan cập nhật – phần II: các ứng dụng lâm sàng khác và biến chứng",{"VOID":2097},"28846134",{"VOID":2099},"10.1111/iej.12843",[388],[390],"https://onlinelibrary.wiley.com/doi/10.1111/iej.12843",[2104,2125,2147],{"id":2105,"sortIndex":110,"researcher":24,"roles":2106,"affiliations":2107,"properties":2118},"fb6040a8-7058-4fcf-9939-8d2fd09f76c1",[],[2108],{"id":2109,"sortIndex":25,"affiliation":2110,"properties":24},"96fda4fb-9ace-4b5b-ad23-1163a7b0f07e",{"id":2111,"createTime":2112,"updateTime":2112,"relativeEntities":2113,"slug":2114,"properties":2115,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"26dd8429-c0e7-463e-bb1b-88dd699f8904","2024-09-21T07:20:06.048+00:00",[],"Endodontology-Research-Center-School-of-Dentistry-Kerman-University-of-Medical-Sciences-Kerman-Iran",{"title":2116},{"EN":2117},"Endodontology Research Center, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran",{"openalex":2119,"orcid":2121,"title":2123},{"VOID":2120},"A5007006528",{"VOID":2122},"https://orcid.org/0000-0003-0370-4997",{"EN":2124},"Masoud Parirokh",{"id":2126,"sortIndex":25,"researcher":24,"roles":2127,"affiliations":2128,"properties":2140},"06da5393-db96-4279-9322-d72e1268db27",[],[2129],{"id":2130,"sortIndex":25,"affiliation":2131,"properties":24},"a7603f14-6335-49db-a2e8-e92633ee4036",{"id":2132,"createTime":2133,"updateTime":2134,"relativeEntities":2135,"slug":2136,"properties":2137,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"c4f18300-280c-4be5-8e6a-a9200a1f45a5","2023-12-27T04:15:14.666+00:00","2024-09-21T07:20:06.038+00:00",[],"Department-of-Endodontics-School-of-Dentistry-Loma-Linda-University-Loma-Linda-CA-USA",{"title":2138},{"VI":2139},"Department of Endodontics, School of Dentistry, Loma Linda University, Loma Linda, CA, USA",{"openalex":2141,"orcid":2143,"title":2145},{"VOID":2142},"A5028287256",{"VOID":2144},"https://orcid.org/0000-0002-1340-0439",{"EN":2146},"Mahmoud Torabinejad",{"id":2148,"sortIndex":123,"researcher":24,"roles":2149,"affiliations":2150,"properties":2162},"5517b19c-cdaf-4edd-abaf-714b033a08d7",[],[2151],{"id":2152,"sortIndex":25,"affiliation":2153,"properties":24},"73633fc0-8d00-49fb-8f68-5900cd4fe88c",{"id":2154,"createTime":2155,"updateTime":2156,"relativeEntities":2157,"slug":2158,"properties":2159,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"7ecff705-f6fe-425a-b3c3-39132d4bb893","2024-01-02T04:23:13.077+00:00","2024-09-21T07:20:06.059+00:00",[],"School-of-Dentistry-College-of-Biomedical-and-Life-Sciences-Cardiff-University-Cardiff-UK",{"title":2160},{"VI":2161},"School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK",{"openalex":2163,"orcid":2165,"title":2167},{"VOID":2164},"A5031674319",{"VOID":2166},"https://orcid.org/0000-0002-0726-7467",{"EN":2168},"P. M. H. Dummer",{"url":24,"publisher":2170,"properties":2261},{"id":2171,"createTime":2172,"updateTime":2173,"relativeEntities":2174,"slug":2175,"properties":2176,"entityType":264,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":2186,"manageAffiliations":2187,"indexDatabases":2188,"url":2210,"thumbnailPath":24,"statistic":2211,"gsStatistic":24,"type":24,"analyzePriority":24},"b346c01f-9345-4533-9784-e9861d1e6cac","2023-05-29T11:16:48.588+00:00","2025-02-08T20:17:14.202+00:00",[],"International-Endodontic-Journal",{"country":2177,"issn":2178,"introduce":2180,"eissn":2182,"title":2184},{"VOID":1248},{"VOID":2179},"13652591",{"EN":2181},"The International Endodontic Journal is published monthly and strives to publish original articles of the highest quality to disseminate scientific and clinical knowledge; all manuscripts are subjected to peer review. Original scientific articles are published in the areas of biomedical science, applied materials science, bioengineering, epidemiology and social science relevant to endodontic disease and its management, and to the restoration of root-treated teeth. In addition, review articles, reports of clinical cases, book reviews, summaries and abstracts of scientific meetings and news items are accepted. The International Endodontic Journal is essential reading for general dental practitioners, specialist endodontists, research, scientists and dental teachers.",{"VOID":2183},"01432885",{"EN":2185},"International Endodontic 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S, 2010, Nonsurgical approach for strip perforation repair using mineral trioxide aggregate, Journal of Conservative Dentistry, 13, 97, 10.4103/0972-0707.66721",{"doi":2283},"10.4103/0972-0707.66721",{"id":24,"text":2285,"url":24,"identifiers":2286},"10.1038/sj.bdj.2010.293",{"doi":2285},{"id":24,"text":2288,"url":24,"identifiers":2289},"10.4103/1305-7456.172625",{"doi":2288},{"id":24,"text":2291,"url":24,"identifiers":2292},"10.1016/j.joen.2016.01.001",{"doi":2291},{"id":24,"text":2294,"url":24,"identifiers":2295},"10.4103/0976-9668.127336",{"doi":2294},{"id":24,"text":2297,"url":24,"identifiers":2298},"Ajwani P, 2011, Non‐surgical management of a mutilated maxillary central incisor with open apex and large periapical lesion, Indian Journal of Dental Research, 22, 475, 10.4103/0970-9290.87074",{"doi":2299},"10.4103/0970-9290.87074",{"id":24,"text":2301,"url":24,"identifiers":2302},"10.1155/2012/563203",{"doi":2301},{"id":24,"text":2304,"url":24,"identifiers":2305},"10.1111/j.1600-9657.2012.01128.x",{"doi":2304},{"id":24,"text":2307,"url":24,"identifiers":2308},"10.1016/j.tripleo.2006.09.007",{"doi":2307},{"id":24,"text":2310,"url":24,"identifiers":2311},"Aldakak MM, 2016, Single‐visit pulp revascularization of a nonvital immature permanent tooth using Biodentine, Iranian Endodontic Journal, 11, 246",{},{"id":24,"text":2313,"url":24,"identifiers":2314},"Al‐Ghamdi NS, 2015, Pulp revascularization of immature maxillary first premolar, Journal of Conservative Dentistry, 18, 496, 10.4103/0972-0707.168824",{"doi":2315},"10.4103/0972-0707.168824",{"id":24,"text":2317,"url":24,"identifiers":2318},"Al‐Kahtani A, 2013, Avulsed immature permanent central incisors obturated with mineral trioxide aggregate: a case report, Journal of International Oral Health, 5, 88",{},{"id":24,"text":2320,"url":24,"identifiers":2321},"10.1016/j.joen.2014.02.016",{"doi":2320},{"id":24,"text":2323,"url":24,"identifiers":2324},"10.1111/jerd.12264",{"doi":2323},{"id":24,"text":2326,"url":24,"identifiers":2327},"10.1186/s12903-016-0276-y",{"doi":2326},{"id":24,"text":2329,"url":24,"identifiers":2330},"10.1111/iej.12645",{"doi":2329},{"id":24,"text":2332,"url":24,"identifiers":2333},"10.1016/j.joen.2009.06.017",{"doi":2332},{"id":24,"text":2335,"url":24,"identifiers":2336},"Alzraikat H, 2016, Dissolution of a mineral trioxide aggregate sealer in endodontic solvents compared to conventional sealers, Brazilian Oral Research, 30, e16, 10.1590/1807-3107BOR-2016.vol30.0016",{"doi":2337},"10.1590/1807-3107BOR-2016.vol30.0016",{"id":24,"text":2339,"url":24,"identifiers":2340},"Aminabadi NA, 2016, A randomized trial using 3mixtatin compared to MTA in primary molars with inflammatory root resorption: a novel endodontic biomaterial, Journal of Clinical Pediatric Dentistry, 40, 95, 10.17796/1053-4628-40.2.95",{"doi":2341},"10.17796/1053-4628-40.2.95",{"id":24,"text":2343,"url":24,"identifiers":2344},"Aminov L, 2012, Clinical‐radiological study on the role of biostimulating materials in iatrogenic furcation lesions, Revista Medico‐Chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116, 907",{},{"id":24,"text":2346,"url":24,"identifiers":2347},"10.17796/jcpd.35.2.9061h7g718834017",{"doi":2346},{"id":24,"text":2349,"url":24,"identifiers":2350},"10.2334/josnusd.52.325",{"doi":2349},{"id":24,"text":2352,"url":24,"identifiers":2353},"Arikan V, 2010, Comparison of two base materials regarding their effect on root canal treatment success in primary molars with furcation lesions, European Journal of Dentistry, 4, 447",{},{"id":24,"text":2355,"url":24,"identifiers":2356},"Arman M, 2015, In vitro spectrophotometry of tooth discoloration induced by tooth‐colored mineral trioxide aggregate and calcium‐enriched mixture cement, Iranian Endodontic Journal, 10, 226",{},{"id":24,"text":2358,"url":24,"identifiers":2359},"Arora S, 2015, Management of a rare case of communicating internal‐external inflammatory resorption, Journal of Clinical and Diagnostic Research, 9, ZD39",{},{"id":24,"text":2361,"url":24,"identifiers":2362},"10.1097/01.DON.0000133156.85164.B2",{"doi":2361},{"id":24,"text":2364,"url":24,"identifiers":2365},"Asgary S, 2009, Autogenous transplantation of mandibular third molar to replace tooth with vertical root fracture, Iranian Endodontic Journal, 4, 117",{},{"id":24,"text":2367,"url":24,"identifiers":2368},"10.4103/0972-0707.71650",{"doi":2367},{"id":24,"text":2370,"url":24,"identifiers":2371},"10.1016/j.joen.2010.03.005",{"doi":2370},{"id":24,"text":2373,"url":24,"identifiers":2374},"Asgary S, 2011, Management of a hopeless mandibular molar: a case report, Iranian Endodontic Journal, 6, 34",{},{"id":24,"text":2376,"url":24,"identifiers":2377},"10.1016/j.joen.2010.11.015",{"doi":2376},{"id":24,"text":2379,"url":24,"identifiers":2380},"Asgary S, 2012, One‐visit endodontic retreatment of combined external/internal root resorption using a calcium‐enriched mixture, General Dentistry, 60, e244",{},{"id":24,"text":2382,"url":24,"identifiers":2383},"Asgary S, 2012, Root canal obturation of an open apex root with calcium enriched mixture, International Journal of Case Reports and Images, 23, 50, 10.5348/ijcri-2012-05-126-CR-11",{"doi":2384},"10.5348/ijcri-2012-05-126-CR-11",{"id":24,"text":2386,"url":24,"identifiers":2387},"10.1016/j.sdentj.2011.08.001",{"doi":2386},{"id":24,"text":2389,"url":24,"identifiers":2390},"Asgary S, 2013, Periradicular surgery of human permanent teeth with calcium‐enriched mixture cement, Iranian Endodontic Journal, 8, 140",{},{"id":24,"text":2392,"url":24,"identifiers":2393},"Asgary S, 2013, Twenty years of research on mineral trioxide aggregate, a scientometric report, Iranian Endodontic Journal, 8, 1",{},{"id":24,"text":2395,"url":24,"identifiers":2396},"Asgary S, 2014, Nonsurgical management of an extensive endodontic lesion in an orthodontic patient by calcium‐enriched mixture apical plug, Contemporary Clinical Dentistry, 5, 278, 10.4103/0976-237X.132358",{"doi":2397},"10.4103/0976-237X.132358",{"id":24,"text":2399,"url":24,"identifiers":2400},"Asgary S, 2015, Surgical repair of invasive cervical root resorption with calcium‐enriched mixture cement: a case report, General Dentistry, 63, 37",{},{"id":24,"text":2402,"url":24,"identifiers":2403},"10.1016/j.joen.2016.05.001",{"doi":2402},{"id":24,"text":2405,"url":24,"identifiers":2406},"Asgary S, 2014, Indications and case series of intentional replantation of teeth, Iranian Endodontic Journal, 9, 71",{},{"id":24,"text":2408,"url":24,"identifiers":2409},"10.5395/rde.2014.39.2.137",{"doi":2408},{"id":24,"text":2411,"url":24,"identifiers":2412},"Asgary S, 2015, Surgical treatment of an immature short‐rooted traumatized incisor with an extensive apical lesion using CEM cement, Iranian Endodontic Journal, 10, 148",{},{"id":24,"text":2414,"url":24,"identifiers":2415},"10.17796/1053-4628-40.5.356",{"doi":2414},{"id":24,"text":2417,"url":24,"identifiers":2418},"Ashkenazi M, 2015, The diagnostic and treatment challenges associated with traumatized intruded permanent incisors: a case report, Quintessence International, 46, 309",{},{"id":24,"text":2420,"url":24,"identifiers":2421},"Ashouri R, 2012, Surgical intervention for treating an extensive internal resorption with unfavorable crown‐to‐root ratio, Journal of Conservative Dentistry, 15, 388, 10.4103/0972-0707.101922",{"doi":2422},"10.4103/0972-0707.101922",{"id":24,"text":2424,"url":24,"identifiers":2425},"Ashwini TS, 2013, Role of mineral trioxide aggregate in management of external root resorption, Journal of Conservative Dentistry, 16, 579, 10.4103/0972-0707.120937",{"doi":2426},"10.4103/0972-0707.120937",{"id":24,"text":2428,"url":24,"identifiers":2429},"10.1016/j.joen.2013.12.013",{"doi":2428},{"id":24,"text":2431,"url":24,"identifiers":2432},"10.1016/j.joen.2010.06.022",{"doi":2431},{"id":24,"text":2434,"url":24,"identifiers":2435},"10.1016/j.joen.2010.04.008",{"doi":2434},{"id":24,"text":2437,"url":24,"identifiers":2438},"10.4103/0976-237X.101100",{"doi":2437},{"id":24,"text":2440,"url":24,"identifiers":2441},"Bajwa NK, 2015, Single visit apexification procedure of a traumatically injured tooth with a novel bioinductive material (Biodentine), International Journal of Clinical Pediatric Dentistry, 8, 58, 10.5005/jp-journals-10005-1284",{"doi":2442},"10.5005/jp-journals-10005-1284",{"id":24,"text":2444,"url":24,"identifiers":2445},"Bakhtiar H, 2014, The plasma‐rich in growth factor as a suitable matrix in regenerative endodontics: a case series, New York State Dental Journal, 80, 49",{},{"id":24,"text":2447,"url":24,"identifiers":2448},"10.1007/s00784-016-1967-0",{"doi":2447},{"id":24,"text":2450,"url":24,"identifiers":2451},"Baranwal AK, 2016, Management of external invasive cervical resorption of tooth with Biodentine: a case report, Journal of Conservative Dentistry, 19, 296, 10.4103/0972-0707.181952",{"doi":2452},"10.4103/0972-0707.181952",{"id":24,"text":2454,"url":24,"identifiers":2455},"10.1016/j.joen.2015.08.032",{"doi":2454},{"id":24,"text":2457,"url":24,"identifiers":2458},"10.1016/j.joen.2011.04.003",{"doi":2457},{"id":24,"text":2460,"url":24,"identifiers":2461},"10.1016/j.joen.2014.10.007",{"doi":2460},{"id":24,"text":2463,"url":24,"identifiers":2464},"Berger T, 2014, In vitro investigations into the etiology of mineral trioxide tooth staining, Journal of Conservative Dentistry, 17, 526, 10.4103/0972-0707.144584",{"doi":2465},"10.4103/0972-0707.144584",{"id":24,"text":2467,"url":24,"identifiers":2468},"10.1016/j.tripleo.2009.07.019",{"doi":2467},{"id":24,"text":2470,"url":24,"identifiers":2471},"10.1590/0103-6440201302242",{"doi":2470},{"id":24,"text":2473,"url":24,"identifiers":2474},"10.1016/j.tripleo.2009.08.038",{"doi":2473},{"id":24,"text":2476,"url":24,"identifiers":2477},"10.1111/iej.12144",{"doi":2476},{"id":24,"text":2479,"url":24,"identifiers":2480},"10.1016/j.joen.2014.10.004",{"doi":2479},{"id":24,"text":2482,"url":24,"identifiers":2483},"10.1111/aej.12132",{"doi":2482},{"id":24,"text":2485,"url":24,"identifiers":2486},"Bharti R, 2014, Management of mucosal fenestration with external root resorption by multidisciplinary approach, BMJ Case Report, 2014, 10.1136/bcr-2014-206259",{"doi":2487},"10.1136/bcr-2014-206259",{"id":24,"text":2489,"url":24,"identifiers":2490},"Biswas M, 2011, Non surgical perforation repair by mineral trioxide aggregate under dental operating microscope, Journal of Conservative Dentistry, 14, 83, 10.4103/0972-0707.80729",{"doi":2491},"10.4103/0972-0707.80729",{"id":24,"text":2493,"url":24,"identifiers":2494},"10.1007/s00784-014-1348-5",{"doi":2493},{"id":24,"text":2496,"url":24,"identifiers":2497},"Borges AH, 2014, Portland cement use in dental root perforations: a long term follow up, Case Report Dentistry, 2014, 637693",{},{"id":24,"text":2499,"url":24,"identifiers":2500},"10.1016/j.joen.2014.12.022",{"doi":2499},{"id":24,"text":2502,"url":24,"identifiers":2503},"10.1016/j.joen.2009.06.021",{"doi":2502},{"id":24,"text":2505,"url":24,"identifiers":2506},"10.1016/j.tripleo.2010.07.008",{"doi":2505},{"id":24,"text":2508,"url":24,"identifiers":2509},"Brito‐Junior M, 2012, Orthograde retreatment failure with extruded MTA apical plug in a large periradicular lesion followed by surgical intervention: case report, General Dentistry, 60, e96",{},{"id":24,"text":2511,"url":24,"identifiers":2512},"Bücher K, 2016, Long‐term outcome of MTA apexification in teeth with open apices, Quintessence International, 47, 473",{},{"id":24,"text":2514,"url":24,"identifiers":2515},"10.1016/j.joen.2016.06.021",{"doi":2514},{"id":24,"text":2517,"url":24,"identifiers":2518},"Butt N, 2013, In‐vitro evaluation of various solvents for retrieval of mineral trioxide aggregate and their effect on microhardness of dentin, Journal of Conservative Dentistry, 16, 199, 10.4103/0972-0707.111313",{"doi":2519},"10.4103/0972-0707.111313",{"id":24,"text":2521,"url":24,"identifiers":2522},"10.1111/iej.12451",{"doi":2521},{"id":24,"text":2524,"url":24,"identifiers":2525},"10.1016/j.joen.2013.09.040",{"doi":2524},{"id":24,"text":2527,"url":24,"identifiers":2528},"10.1016/j.joen.2015.02.032",{"doi":2527},{"id":24,"text":2530,"url":24,"identifiers":2531},"10.1038/ijos.2014.25",{"doi":2530},{"id":24,"text":2533,"url":24,"identifiers":2534},"10.1016/j.joen.2013.10.020",{"doi":2533},{"id":24,"text":2536,"url":24,"identifiers":2537},"10.1016/j.joen.2011.05.033",{"doi":2536},{"id":24,"text":2539,"url":24,"identifiers":2540},"10.1111/j.1600-9657.2010.00941.x",{"doi":2539},{"id":24,"text":2542,"url":24,"identifiers":2543},"Ceyhanli KT, 2014, Conservative treatment and follow‐up of type III dens invaginatus using cone beam computed tomography, Journal of Oral Science, 56, 307, 10.2334/josnusd.56.307",{"doi":2544},"10.2334/josnusd.56.307",{"id":24,"text":2546,"url":24,"identifiers":2547},"Chakraborty A, 2012, Healing of apical rarefaction of three nonvital open apex anterior teeth using a white portland cement apical plug, Contemporary Clinical Dentistry, 3, S177, 10.4103/0976-237X.101101",{"doi":2548},"10.4103/0976-237X.101101",{"id":24,"text":2550,"url":24,"identifiers":2551},"10.1016/j.tripleo.2011.03.047",{"doi":2550},{"id":24,"text":2553,"url":24,"identifiers":2554},"10.5005/jp-journals-10005-1268",{"doi":2553},{"id":24,"text":2556,"url":24,"identifiers":2557},"10.1038/ijos.2013.16",{"doi":2556},{"id":24,"text":2559,"url":24,"identifiers":2560},"10.1111/iej.12237",{"doi":2559},{"id":24,"text":2562,"url":24,"identifiers":2563},"10.1111/j.1365-2591.2011.01978.x",{"doi":2562},{"id":24,"text":2565,"url":24,"identifiers":2566},"10.1016/j.joen.2014.11.005",{"doi":2565},{"id":24,"text":2568,"url":24,"identifiers":2569},"Chhabra N, 2010, Successful apexification with resolution of the periapical lesion using mineral trioxide aggregate and demineralized freeze‐dried bone allograft, Journal of Conservative Dentistry, 13, 106, 10.4103/0972-0707.66723",{"doi":2570},"10.4103/0972-0707.66723",{"id":24,"text":2572,"url":24,"identifiers":2573},"10.5395/rde.2014.39.2.126",{"doi":2572},{"id":24,"text":2575,"url":24,"identifiers":2576},"10.1016/j.tripleo.2005.01.010",{"doi":2575},{"id":24,"text":2578,"url":24,"identifiers":2579},"10.1111/j.1365-2591.2008.01474.x",{"doi":2578},{"id":24,"text":2581,"url":24,"identifiers":2582},"10.1111/j.1600-9657.2010.00940.x",{"doi":2581},{"id":24,"text":2584,"url":24,"identifiers":2585},"Chute AK, 2014, Repair of incomplete horizontal mid‐root fracture of maxillary central incisor with mineral trioxide aggregate: a follow up report, Journal of Conservative Dentistry, 17, 393, 10.4103/0972-0707.136521",{"doi":2586},"10.4103/0972-0707.136521",{"id":24,"text":2588,"url":24,"identifiers":2589},"Çiçek E, 2015, Intraradicular 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10.4103/1305-7456.156789",{"doi":3610},"10.4103/1305-7456.156789",{"id":24,"text":3612,"url":24,"identifiers":3613},"10.1155/2012/257832",{"doi":3612},{"id":24,"text":3615,"url":24,"identifiers":3616},"10.1016/j.joen.2016.10.010",{"doi":3615},{"id":24,"text":3618,"url":24,"identifiers":3619},"10.1016/j.joen.2012.09.001",{"doi":3618},{"id":24,"text":3621,"url":24,"identifiers":3622},"10.1016/j.joen.2015.08.026",{"doi":3621},{"id":3624,"createTime":3625,"updateTime":3626,"relativeEntities":3627,"slug":3628,"properties":3629,"entityType":20,"verifyStatus":384,"verifyTime":3625,"verifyNote":385,"syncStatus":386,"languages":3644,"translateLanguages":3645,"viewCount":25,"primaryUrl":3646,"fullTextUrl":24,"authors":3647,"publicationType":22,"publisherRelationship":3702,"citationCount":938,"citationInfo":3782,"publishDate":3785,"publishYear":2275,"citationAnalyzeStatus":386,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":3786,"isForceReanalyzing":26},"a40239c5-484b-413a-bc1d-ef4af344c2d6","2024-10-12T01:45:47.813+00:00","2024-12-24T09:47:21.159+00:00",[],"Using-residualized-change-versus-difference-scores-for-longitudinal-research",{"mag":3630,"keywords":3632,"openalex":3634,"abstract":3636,"title":3639,"doi":3642},{"VOID":3631},"2780493514",{"VI":3633},"nghiên cứu dọc, thay đổi dư thừa, điểm khác biệt, nghịch lý Lord, mối quan hệ, sống thử, sự hài lòng trong mối quan hệ, nghiên cứu không ngẫu nhiên, mô hình hóa dữ liệu, khung điểm thay đổi tiềm ẩn",{"VOID":3635},"W2780493514",{"EN":3637,"VI":3638},"\u003Cjats:p> Researchers interested in studying change over time are often faced with an analytical conundrum: Whether a residualized change model versus a difference score model should be used to assess the effect of a key predictor on change that took place between two occasions. In this article, the authors pose a motivating example in which a researcher wants to investigate the effect of cohabitation on pre- to post-marriage change in relationship satisfaction. Key features of this example include the likely self-selection of dyads with lower relationship satisfaction to cohabit and the impossibility of using experimentation procedures to attain equivalent groups (i.e., cohabitants vs. not cohabitants). The authors use this example of a nonrandomized study to compare the residualized change and difference score models analytically and empirically. The authors describe the assumptions of the models to explain Lord’s paradox; that is, the fact that these models can lead to different inferences about the effect under investigation. They also provide recommendations for modeling data from nonrandomized studies using a latent change score framework. \u003C/jats:p>","\u003Cjats:p> Các nhà nghiên cứu quan tâm đến việc nghiên cứu sự thay đổi theo thời gian thường đối mặt với một nghịch lý phân tích: liệu một mô hình thay đổi dư thừa so với một mô hình điểm khác biệt nên được sử dụng để đánh giá tác động của một dự đoán quan trọng đối với sự thay đổi diễn ra giữa hai thời điểm. Trong bài viết này, các tác giả nêu ra một ví dụ thúc đẩy trong đó một nhà nghiên cứu muốn điều tra ảnh hưởng của sống thử đến sự thay đổi về sự hài lòng trong mối quan hệ từ trước đến sau hôn nhân. Các đặc điểm chính của ví dụ này bao gồm khả năng tự chọn của các cặp đôi có mức hài lòng trong mối quan hệ thấp hơn để sống thử và sự không thể sử dụng các thủ tục thí nghiệm để đạt được các nhóm tương đương (tức là, những người sống thử so với không sống thử). Các tác giả sử dụng ví dụ về một nghiên cứu không ngẫu nhiên để so sánh các mô hình thay đổi dư thừa và điểm khác biệt một cách phân tích và thực nghiệm. Các tác giả mô tả các giả định của các mô hình để giải thích nghịch lý Lord; đó là thực tế rằng các mô hình này có thể dẫn đến các suy luận khác nhau về tác động đang được điều tra. Họ cũng cung cấp các khuyến nghị cho việc mô hình hóa dữ liệu từ các nghiên cứu không ngẫu nhiên bằng cách sử dụng khung điểm thay đổi tiềm ẩn. \u003C/jats:p>",{"EN":3640,"VI":3641},"Using residualized change versus difference scores for longitudinal research","Sử dụng mô hình thay đổi dư thừa so với số điểm khác biệt cho nghiên cứu dọc",{"VOID":3643},"10.1177/0265407517718387",[388],[390],"https://journals.sagepub.com/doi/10.1177/0265407517718387",[3648,3670],{"id":3649,"sortIndex":110,"researcher":24,"roles":3650,"affiliations":3651,"properties":3663},"ca0d1fbd-dbfd-4a54-beb1-f9f56262bdc5",[],[3652],{"id":3653,"sortIndex":25,"affiliation":3654,"properties":24},"0d700689-c99c-4a22-bce2-6a5a82d1008f",{"id":3655,"createTime":3656,"updateTime":3657,"relativeEntities":3658,"slug":3659,"properties":3660,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"381a90a2-1792-4747-8ad1-4296cecf3dd4","2024-01-15T16:13:26.293+00:00","2024-10-12T01:45:47.847+00:00",[],"Arizona-State-University-USA",{"title":3661},{"VI":3662},"Arizona State University, USA",{"openalex":3664,"orcid":3666,"title":3668},{"VOID":3665},"A5060956262",{"VOID":3667},"https://orcid.org/0000-0002-8576-4469",{"EN":3669},"Kevin J. 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JSPR is the leading journal in the field, publishing empirical and theoretical papers on social and personal relationships. 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J., 2001, Structural equation modeling: Present and future. A Festschrift in honor of Karl Jöreskog, 341",{},{"id":24,"text":3833,"url":24,"identifiers":3834},"10.2307/1130295",{"doi":3833},{"id":24,"text":3836,"url":24,"identifiers":3837},"10.1037/10409-005",{"doi":3836},{"id":24,"text":3839,"url":24,"identifiers":3840},"McArdle J. J., 1994, Life-span developmental psychology: Methodological innovations, 223",{},{"id":24,"text":3842,"url":24,"identifiers":3843},"10.1007/BF02294746",{"doi":3842},{"id":24,"text":3845,"url":24,"identifiers":3846},"Muthén L. K., 1998, User’s guide, 7",{},{"id":24,"text":3848,"url":24,"identifiers":3849},"Pearl J. (2014, 10 3). Lord’s paradox revisited – (Oh Lord! Kumbaya!). Technical Report. Retrieved from http://ftp.cs.ucla.edu/pub/stat_ser/r436.pdf",{"doi":3850},"10.21236/ADA615058",{"id":24,"text":3852,"url":24,"identifiers":3853},"10.1037/0033-2909.92.3.726",{"doi":3852},{"id":24,"text":3855,"url":24,"identifiers":3856},"10.1111/j.1745-3984.1983.tb00211.x",{"doi":3855},{"id":24,"text":3858,"url":24,"identifiers":3859},"10.1080/00273171.2013.831743",{"doi":3858},{"id":24,"text":3861,"url":24,"identifiers":3862},"10.1037/0033-2909.109.1.147",{"doi":3861},{"id":24,"text":3864,"url":24,"identifiers":3865},"10.1037/10222-009",{"doi":3864},{"id":3867,"createTime":3868,"updateTime":3869,"relativeEntities":3870,"slug":3871,"properties":3872,"entityType":20,"verifyStatus":386,"verifyTime":3868,"verifyNote":3886,"syncStatus":386,"languages":3887,"translateLanguages":3888,"viewCount":25,"primaryUrl":3889,"fullTextUrl":24,"authors":3890,"publicationType":22,"publisherRelationship":3922,"citationCount":958,"citationInfo":4070,"publishDate":4072,"publishYear":4073,"citationAnalyzeStatus":386,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":4074,"isForceReanalyzing":26},"346153ea-473a-4505-9f58-c123ec107d34","2025-02-05T17:49:51.798+00:00","2025-02-14T18:57:59.665+00:00",[],"Determining-the-standoff-distance-of-the-bow-shock-Mach-number-dependence-and-use-of-models",{"mag":3873,"keywords":3875,"openalex":3876,"abstract":3878,"title":3881,"doi":3884},{"VOID":3874},"1978090441",{"VI":58},{"VOID":3877},"W1978090441",{"EN":3879,"VI":3880},"\u003Cjats:p>We explore the factors that determine the bow shock standoff distance. These factors include the parameters of the solar wind, such as the magnetosonic Mach number, plasma beta, and magnetic field orientation, as well as the size and shape of the obstacle. In this report we develop a semiempirical Mach number relation for the bow shock standoff distance in order to take into account the shock's behavior at low Mach numbers. This is done by determining which properties of the shock are most important in controlling the standoff distance and using this knowledge to modify the current Mach number relation. While the present relation has proven useful at higher Mach numbers, it has lacked effectiveness at the low Mach number limit. We also analyze the bow shock dependence upon the size and shape of the obstacle, noting that it is most appropriate to compare the standoff distance of the bow shock to the radius of curvature of the obstacle, as opposed to the distance from the focus of the object to the nose. Last, we focus our attention on the use of bow shock models in determining the standoff distance. We note that the physical behavior of the shock must correctly be taken into account, specifically the behavior as a function of solar wind dynamic pressure; otherwise, erroneous results can be obtained for the bow shock standoff distance.\u003C/jats:p>","\u003Cjats:p>Chúng tôi khảo sát các yếu tố xác định khoảng cách đứng yên của sóng sốc mũi. Những yếu tố này bao gồm các tham số của gió mặt trời, chẳng hạn như số Mach magnetosonic, beta plasma và phương hướng của trường từ, cũng như kích thước và hình dạng của trở ngại. Trong báo cáo này, chúng tôi phát triển một mối quan hệ số Mach bán thực nghiệm cho khoảng cách đứng yên của sóng sốc mũi nhằm tính đến hành vi của sóng sốc tại các số Mach thấp. Điều này được thực hiện bằng cách xác định những thuộc tính nào của sóng sốc là quan trọng nhất trong việc kiểm soát khoảng cách đứng yên và sử dụng kiến thức này để điều chỉnh mối quan hệ số Mach hiện tại. Trong khi mối quan hệ hiện tại đã chứng tỏ là hữu ích ở các số Mach cao, nó thiếu hiệu quả ở giới hạn số Mach thấp. Chúng tôi cũng phân tích sự phụ thuộc của sóng sốc mũi vào kích thước và hình dạng của trở ngại, lưu ý rằng phù hợp nhất là so sánh khoảng cách đứng yên của sóng sốc mũi với bán kính cong của trở ngại, thay vì khoảng cách từ tâm của vật thể đến mũi. Cuối cùng, chúng tôi tập trung vào việc sử dụng các mô hình sóng sốc mũi trong việc xác định khoảng cách đứng yên. Chúng tôi nhận thấy rằng hành vi vật lý của sóng sốc phải được xem xét một cách chính xác, cụ thể là hành vi như một hàm của áp suất động học của gió mặt trời; nếu không, có thể thu được những kết quả sai cho khoảng cách đứng yên của sóng sốc mũi.\u003C/jats:p>",{"EN":3882,"VI":3883},"Determining the standoff distance of the bow shock: Mach number dependence and use of models","Xác định khoảng cách đứng yên của sóng sốc mũi: Sự phụ thuộc vào số Mach và việc sử dụng các mô hình",{"VOID":3885},"10.1029/94ja01020","Author affiliation is blank",[388],[390],"https://agupubs.onlinelibrary.wiley.com/doi/10.1029/94JA01020",[3891,3911],{"id":3892,"sortIndex":25,"researcher":24,"roles":3893,"affiliations":3894,"properties":3906},"e4d8eddf-6be2-4dc8-a864-f3a4c214d3c6",[],[3895],{"id":3896,"sortIndex":25,"affiliation":3897,"properties":24},"9695b9c0-c420-452f-bd77-be327c8f51ad",{"id":3898,"createTime":3899,"updateTime":3900,"relativeEntities":3901,"slug":3902,"properties":3903,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"4a40fbb9-af08-4e37-9d73-e0dd043e1357","2024-10-07T07:32:03.775+00:00","2025-02-05T17:49:51.807+00:00",[],"University-of-California-Los-Angeles-CA-United-States-",{"title":3904},{"EN":3905},"University of California Los Angeles, CA (United States)",{"openalex":3907,"title":3909},{"VOID":3908},"A5025341124",{"EN":3910},"M. 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H. D. H.Fairfield R. R.Anderson A. J.Lazarus J. G.Lyon Unusual locations of Earth's bow shock on 24–25 September 1987: Mach number effectsSpring MeetingAGUBaltimore MD 1993.",{},{"id":24,"text":4082,"url":24,"identifiers":4083},"10.1029/JA076i028p06700",{"doi":4082},{"id":24,"text":4085,"url":24,"identifiers":4086},"10.1029/91GL02090",{"doi":4085},{"id":24,"text":4088,"url":24,"identifiers":4089},"Landau L. D., 1959, Fluid Mechanics",{},{"id":24,"text":4091,"url":24,"identifiers":4092},"Kreyszig E., 1988, Advanced Engineering Mathematics, 479",{},{"id":24,"text":4094,"url":24,"identifiers":4095},"10.1016/0021-9169(91)90051-8",{"doi":4094},{"id":24,"text":4097,"url":24,"identifiers":4098},"Peredo M. E.Mazur J. A.Slavin S. A.Curtis The bow shock: A three‐dimensional model for arbitrary solar wind dynamic pressure IMF orientation and Alfvénic Mach numberSpring MeetingAGUBaltimore MD 1993.",{},{"id":24,"text":4100,"url":24,"identifiers":4101},"10.1029/92GL00634",{"doi":4100},{"id":24,"text":4103,"url":24,"identifiers":4104},"Seiff A. Gasdynamics in space exploration NASA Spec. Publ. 24 1962.",{},{"id":24,"text":4106,"url":24,"identifiers":4107},"10.1029/JA086iA13p11401",{"doi":4106},{"id":24,"text":4109,"url":24,"identifiers":4110},"10.1016/0032-0633(66)90124-3",{"doi":4109},{"id":4112,"createTime":4113,"updateTime":4114,"relativeEntities":4115,"slug":4116,"properties":4117,"entityType":20,"verifyStatus":384,"verifyTime":4114,"verifyNote":385,"syncStatus":386,"languages":4136,"translateLanguages":4137,"viewCount":25,"primaryUrl":4138,"fullTextUrl":24,"authors":4139,"publicationType":22,"publisherRelationship":4195,"citationCount":4298,"citationInfo":4299,"publishDate":4301,"publishYear":4302,"citationAnalyzeStatus":4303,"lastCitationAnalyze":4304,"indexDatabases":24,"openAccess":24,"references":4305,"isForceReanalyzing":26},"e3222712-53a2-46f0-a9ce-79261ff1e672","2024-04-13T22:58:23.378+00:00","2025-02-08T02:26:53.435+00:00",[],"A-rapid-non-invasive-procedure-for-quantitative-assessment-of-drought-survival-using-chlorophyll-fluorescence",{"mag":4118,"keywords":4120,"pmc":4122,"openalex":4124,"abstract":4126,"title":4129,"pm":4132,"doi":4134},{"VOID":4119},"2171912545",{"VI":4121},"Hạn hán, khả năng sống sót, huỳnh quang diệp lục, \u003Cjats:italic>Arabidopsis thaliana\u003C/jats:italic>, đo không xâm lấn",{"VOID":4123},"2628343",{"VOID":4125},"W2171912545",{"VI":4127,"EN":4128},"\u003Cjats:title>Tóm tắt\u003C/jats:title>\n \u003Cjats:sec>\n \u003Cjats:title>Nền tảng\u003C/jats:title>\n \u003Cjats:p>Phân tích khả năng sống sót thường được sử dụng như một phương tiện để so sánh hiệu suất của các dòng thực vật dưới điều kiện hạn hán. Tuy nhiên, việc đánh giá tình trạng nước của thực vật trong các nghiên cứu như vậy thường liên quan đến việc tách rời để ước lượng cú sốc nước, những phương pháp ước lượng không chính xác hoặc các phép đo xâm lấn như điều chỉnh thẩm thấu, ảnh hưởng đến hoặc hủy bỏ sự đánh giá tiếp theo về phản ứng của mẫu vật đối với hạn hán.\u003C/jats:p>\n \u003C/jats:sec>\n \u003Cjats:sec>\n \u003Cjats:title>Kết quả\u003C/jats:title>\n \u003Cjats:p>Bài báo này trình bày một quy trình để đánh giá nhanh chóng, giá rẻ và không xâm lấn khả năng sống sót của các cây trồng trên đất trong quá trình điều trị hạn hán. Những thay đổi trong các tham số quang hợp chính trong điều kiện thiếu nước ngày càng tăng đã được theo dõi thông qua hình ảnh huỳnh quang diệp lục và lựa chọn tham số hiệu suất tối đa của hệ thống quang hợp II (F\u003Cjats:sub>v\u003C/jats:sub>/F\u003Cjats:sub>m\u003C/jats:sub>) như một phương tiện đơn giản và thực tiễn nhất để theo dõi khả năng sống sót được mô tả. Tính hợp lệ của kỹ thuật này được xác minh thông qua ứng dụng với nhiều loại hình sinh thái và các dòng đột biến của \u003Cjats:italic>Arabidopsis thaliana\u003C/jats:italic> có khả năng chịu hạn thay đổi hoặc hiệu suất quang hợp giảm.","\u003Cjats:title>Abstract\u003C/jats:title>\n \u003Cjats:sec>\n \u003Cjats:title>Background\u003C/jats:title>\n \u003Cjats:p>Analysis of survival is commonly used as a means of comparing the performance of plant lines under drought. However, the assessment of plant water status during such studies typically involves detachment to estimate water shock, imprecise methods of estimation or invasive measurements such as osmotic adjustment that influence or annul further evaluation of a specimen's response to drought.\u003C/jats:p>\n \u003C/jats:sec>\n \u003Cjats:sec>\n \u003Cjats:title>Results\u003C/jats:title>\n \u003Cjats:p>This article presents a procedure for rapid, inexpensive and non-invasive assessment of the survival of soil-grown plants during drought treatment. The changes in major photosynthetic parameters during increasing water deficit were monitored via chlorophyll fluorescence imaging and the selection of the maximum efficiency of photosystem II (F\u003Cjats:sub>v\u003C/jats:sub>/F\u003Cjats:sub>m\u003C/jats:sub>) parameter as the most straightforward and practical means of monitoring survival is described. The veracity of this technique is validated through application to a variety of \u003Cjats:italic>Arabidopsis thaliana\u003C/jats:italic> ecotypes and mutant lines with altered tolerance to drought or reduced photosynthetic efficiencies.\u003C/jats:p>\n \u003C/jats:sec>\n \u003Cjats:sec>\n \u003Cjats:title>Conclusion\u003C/jats:title>\n \u003Cjats:p>The method presented here allows the acquisition of quantitative numerical estimates of \u003Cjats:italic>Arabidopsis\u003C/jats:italic> drought survival times that are amenable to statistical analysis. Furthermore, the required measurements can be obtained quickly and non-invasively using inexpensive equipment and with minimal expertise in chlorophyll fluorometry. This technique enables the rapid assessment and comparison of the relative viability of germplasm during drought, and may complement detailed physiological and water relations studies.\u003C/jats:p>\n \u003C/jats:sec>",{"VI":4130,"EN":4131},"Một quy trình nhanh chóng, không xâm lấn để đánh giá định lượng khả năng sống sót trong điều kiện hạn hán bằng cách sử dụng huỳnh quang diệp lục","A rapid, non-invasive procedure for quantitative assessment of drought survival using chlorophyll fluorescence",{"VOID":4133},"19014425",{"VOID":4135},"10.1186/1746-4811-4-27",[388],[390],"https://plantmethods.biomedcentral.com/articles/10.1186/1746-4811-4-27",[4140,4160,4179],{"id":4141,"sortIndex":110,"researcher":24,"roles":4142,"affiliations":4143,"properties":4153},"98e6e32b-198b-4749-8a1d-22088bbcbd9b",[],[4144],{"id":24,"sortIndex":25,"affiliation":4145,"properties":24},{"id":4146,"createTime":4147,"updateTime":4147,"relativeEntities":4148,"slug":4149,"properties":4150,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"1b17b9aa-648b-4a00-a211-a6c935b6f046","2024-04-13T22:58:23.400+00:00",[],"Australian-Research-Council-Centre-of-Excellence-in-Plant-Energy-Biology-Research-School-of-Biological-Sciences-the-Australian-National-University-Canberra-ACT-0200-Australia",{"title":4151},{"EN":4152},"Australian Research Council Centre of Excellence in Plant Energy Biology, Research School of Biological Sciences, the Australian National University, Canberra, ACT 0200, Australia",{"openalex":4154,"orcid":4156,"title":4158},{"VOID":4155},"A5032553822",{"VOID":4157},"https://orcid.org/0000-0001-9428-2579",{"EN":4159},"Murray R. Badger",{"id":4161,"sortIndex":25,"researcher":24,"roles":4162,"affiliations":4163,"properties":4174},"67cdfd10-1e97-4d6a-a6b1-b5ea1e4df19a",[],[4164],{"id":24,"sortIndex":25,"affiliation":4165,"properties":24},{"id":4166,"createTime":4167,"updateTime":4168,"relativeEntities":4169,"slug":4170,"properties":4171,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"6dcd07f7-e853-45d9-8e43-34f86925a082","2024-04-13T22:58:23.388+00:00","2024-12-05T09:04:15.604+00:00",[],"Australian-Research-Council-Centre-of-Excellence-in-Plant-Energy-Biology-School-of-Biochemistry-and-Molecular-Biology-the-Australian-National-University-Canberra-ACT-0200-Australia",{"title":4172},{"EN":4173},"Australian Research Council Centre of Excellence in Plant Energy Biology, School of Biochemistry and Molecular Biology, the Australian National University, Canberra, ACT 0200, Australia",{"openalex":4175,"title":4177},{"VOID":4176},"A5080100188",{"EN":4178},"Nick S. Woo",{"id":4180,"sortIndex":123,"researcher":24,"roles":4181,"affiliations":4182,"properties":4188},"4fc29796-f889-45e6-b0e0-09fcb388b991",[],[4183],{"id":24,"sortIndex":25,"affiliation":4184,"properties":24},{"id":4166,"createTime":4167,"updateTime":4168,"relativeEntities":4185,"slug":4170,"properties":4186,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4187},{"EN":4173},{"openalex":4189,"orcid":4191,"title":4193},{"VOID":4190},"A5008465182",{"VOID":4192},"https://orcid.org/0000-0003-1869-2423",{"EN":4194},"Barry J. 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Plant Methods. 2008, 4: 12-10.1186/1746-4811-4-12.",{"doi":4453},"10.1186/1746-4811-4-12",{"id":24,"text":4455,"url":24,"identifiers":4456},"Muller-Moule P, Golan T, Niyogi KK: Ascorbate-deficient mutants of Arabidopsis grow in high light despite chronic photooxidative stress. Plant Physiol. 2004, 134: 1163-1172. 10.1104/pp.103.032375.",{"doi":4457},"10.1104/pp.103.032375",{"id":24,"text":4459,"url":24,"identifiers":4460},"Maxwell K, Johnson GN: Chlorophyll fluorescence – a practical guide. J Exp Bot. 2000, 51: 659-668. 10.1093/jexbot/51.345.659.",{"doi":4461},"10.1093/jexbot/51.345.659",{"id":24,"text":4463,"url":24,"identifiers":4464},"Lawlor DW, Cornic G: Photosynthetic carbon assimilation and associated metabolism in relation to water deficits in higher plants. Plant, Cell and Environment. 2002, 25: 275-294. 10.1046/j.0016-8025.2001.00814.x.",{"doi":4465},"10.1046/j.0016-8025.2001.00814.x",{"id":24,"text":4467,"url":24,"identifiers":4468},"Kramer D, Johnson G, Kiirats O, Edwards G: New fluorescence parameters for the determination of Qa redox state and excitation energy fluxes. Photosynthesis Research. 2004, 79: 209-218. 10.1023/B:PRES.0000015391.99477.0d.",{"doi":4469},"10.1023/B:PRES.0000015391.99477.0d",{"id":24,"text":4471,"url":24,"identifiers":4472},"Rossel JB, Walter PB, Hendrickson L, Chow WS, Poole A, Mullineaux PM, Pogson BJ: A mutation affecting ASCORBATE PEROXIDASE 2 gene expression reveals a link between responses to high light and drought tolerance. Plant, Cell and Environment. 2006, 29: 269-281. 10.1111/j.1365-3040.2005.01419.x.",{"doi":4473},"10.1111/j.1365-3040.2005.01419.x",{"id":24,"text":4475,"url":24,"identifiers":4476},"Mustilli A-C, Merlot S, Vavasseur A, Fenzi F, Giraudat J: Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production. Plant Cell. 2002, 14: 3089-3099. 10.1105/tpc.007906.",{"doi":4477},"10.1105/tpc.007906",{"id":24,"text":4479,"url":24,"identifiers":4480},"Sakamoto W, Tamura T, Hanba-Tomita Y, Murata M: The VAR1 locus of Arabidopsis encodes a chloroplastic FtsH and is responsible for leaf variegation in the mutant alleles. Genes Cells. 2002, 7: 769-780. 10.1046/j.1365-2443.2002.00558.x.",{"doi":4481},"10.1046/j.1365-2443.2002.00558.x",{"id":24,"text":4483,"url":24,"identifiers":4484},"Chen M, Jensen M, Rodermel S: The yellow variegated mutant of Arabidopsis is plastid autonomous and delayed in chloroplast biogenesis. J Hered. 1999, 90: 207-214. 10.1093/jhered/90.1.207.",{"doi":4485},"10.1093/jhered/90.1.207",{"id":24,"text":4487,"url":24,"identifiers":4488},"Mittler R, Kim Y, Song L, Coutu J, Coutu A, Ciftci-Yilmaz S, Lee H, Stevenson B, Zhu J-K: Gain- and loss-of-function mutations in ZAT10 enhance the tolerance of plants to abiotic stress. FEBS letters. 2006, 580: 6537-6542. 10.1016/j.febslet.2006.11.002.",{"doi":4489},"10.1016/j.febslet.2006.11.002",{"id":24,"text":4491,"url":24,"identifiers":4492},"Sakamoto H, Maruyama K, Sakuma Y, Meshi T, Iwabuchi M, Shinozaki K, Yamaguchi-Shinozaki K: Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription repressors under drought, cold, and high-salinity stress conditions. Plant Physiol. 2004, 136: 2734-2746. 10.1104/pp.104.046599.",{"doi":4493},"10.1104/pp.104.046599",{"id":24,"text":4495,"url":24,"identifiers":4496},"Rossel JB, Wilson PB, Hussain D, Woo NS, Gordon MJ, Mewett OP, Howell KA, Whelan J, Kazan K, Pogson BJ: Systemic and intracellular responses to photooxidative stress in Arabidopsis. Plant Cell. 2007, 19: 4091-4110. 10.1105/tpc.106.045898.",{"doi":4497},"10.1105/tpc.106.045898",{"id":24,"text":4499,"url":24,"identifiers":4500},"Gray GR, Hope BJ, Qin X, Taylor BG, Whitehead CL: The characterization of photoinhibition and recovery during cold acclimation in Arabidopsis thaliana using chlorophyll fluorescence imaging. Physiologia Plantarum. 2003, 119: 365-375. 10.1034/j.1399-3054.2003.00224.x.",{"doi":4501},"10.1034/j.1399-3054.2003.00224.x",{"id":24,"text":4503,"url":24,"identifiers":4504},"Rizza F, Pagani D, Stanca AM, Cattivelli L: Use of chlorophyll fluorescence to evaluate the cold acclimation and freezing tolerance of winter and spring oats. Plant Breeding. 2001, 120: 389-396. 10.1046/j.1439-0523.2001.00635.x.",{"doi":4505},"10.1046/j.1439-0523.2001.00635.x",{"id":24,"text":4507,"url":24,"identifiers":4508},"Giardi MT, Cona A, Geiken B, Kuèera T, Masojídek J, Mattoo AK: Long-term drought stress induces structural and functional reorganization of photosystem II. Planta. 1996, 199: 118-125. 10.1007/BF00196888.",{"doi":4509},"10.1007/BF00196888",{"id":24,"text":4511,"url":24,"identifiers":4512},"Hura T, Grzesiak S, Hura K, Thiemt E, Tokarz K, Wedzony M: Physiological and biochemical tools useful in drought-tolerance detection in genotypes of winter triticale: accumulation of ferulic acid correlates with drought tolerance. Annals of Botany. 2007, 100: 767-775. 10.1093/aob/mcm162.",{"doi":4513},"10.1093/aob/mcm162",{"id":24,"text":4515,"url":24,"identifiers":4516},"Flexas J, Bota J, Escalona JM, Sampol B, Medrano H: Effects of drought on photosynthesis in grapevines under field conditions: an evaluation of stomatal and mesophyll limitations. Functional Plant Biology. 2002, 29: 461-471. 10.1071/PP01119.",{"doi":4517},"10.1071/PP01119",{"id":24,"text":4519,"url":24,"identifiers":4520},"Flexas J, Escalona JM, Medrano H: Down-regulation of photosynthesis by drought under field conditions in grapevine leaves. Functional Plant Biology. 1998, 25: 893-900. 10.1071/PP98054.",{"doi":4521},"10.1071/PP98054",{"id":24,"text":4523,"url":24,"identifiers":4524},"Rivero RM, Kojima M, Gepstein A, Sakakibara H, Mittler R, Gepstein S, Blumwald E: Delayed leaf senescence induces extreme drought tolerance in a flowering plant. Proceedings of the National Academy of Sciences. 2007, 104: 19631-19636. 10.1073/pnas.0709453104.",{"doi":4525},"10.1073/pnas.0709453104",{"id":24,"text":4527,"url":24,"identifiers":4528},"Öquist G, Chow WS, Anderson JM: Photoinhibition of photosynthesis represents a mechanism for the long-term regulation of photosystem II. Planta. 1992, 186: 450-460. 10.1007/BF00195327.",{"doi":4529},"10.1007/BF00195327",{"id":24,"text":4531,"url":24,"identifiers":4532},"Cornic G, Gouallec JL, Briantais JM, Hodges M: Effect of dehydration and high light on photosynthesis of two C3 plants (Phaseolus vulgaris L. and Elatostema repens (Lour.) Hall f.). Planta. 1989, 177: 84-90. 10.1007/BF00392157.",{"doi":4533},"10.1007/BF00392157",{"id":24,"text":4535,"url":24,"identifiers":4536},"Hoagland DR, Arnon DA: The water-culture method of growing plants without soil. California Agricultural Experiment Station Circular. 1938, 347: 1-32.",{},{"id":4538,"createTime":4539,"updateTime":4540,"relativeEntities":4541,"slug":4542,"properties":4543,"entityType":20,"verifyStatus":384,"verifyTime":4539,"verifyNote":385,"syncStatus":386,"languages":4558,"translateLanguages":4559,"viewCount":25,"primaryUrl":4560,"fullTextUrl":24,"authors":4561,"publicationType":22,"publisherRelationship":4618,"citationCount":4684,"citationInfo":4685,"publishDate":4687,"publishYear":4688,"citationAnalyzeStatus":386,"lastCitationAnalyze":24,"indexDatabases":24,"openAccess":24,"references":4689,"isForceReanalyzing":26},"e7c66739-495f-40f6-83ee-31a56b0fe661","2024-10-01T20:48:23.602+00:00","2025-02-06T04:18:28.423+00:00",[],"Molecular-mechanisms-of-heavy-metal-tolerance-and-evolution-in-invertebrates",{"mag":4544,"keywords":4546,"openalex":4548,"abstract":4550,"title":4553,"doi":4556},{"VOID":4545},"2120878145",{"VI":4547},"cơ chế phân tử, khả năng chịu đựng kim loại nặng, động vật không xương sống, metallothionein, điều chỉnh phiên mã",{"VOID":4549},"W2120878145",{"EN":4551,"VI":4552},"\u003Cjats:title>Abstract\u003C/jats:title>\u003Cjats:p>Following the genomics revolution, our knowledge of the molecular mechanisms underlying defenses against stress has been greatly expanded. Under strong selective pressure many animals may evolve an enhanced stress tolerance. This can be achieved by altering the structure of proteins (through mutations in the coding regions of genes) or by altering the amount of protein (through changes in transcriptional regulation). The latter type of evolution can be achieved by substitutions in the promoter of the gene of interest (\u003Cjats:italic>cis\u003C/jats:italic>‐regulatory change) or by altering the structure or amount of transcriptional regulator proteins (\u003Cjats:italic>trans\u003C/jats:italic>‐regulatory change). The metallothionein system is one of the best studied stress response systems in the context of heavy metals. Metallothionein expression is assumed to be regulated by metal transcription factor 1 (MTF‐1); however, up to now the involvement of MTF‐1 has only been proven for some vertebrates and \u003Cjats:italic>Drosophila.\u003C/jats:italic> Data on invertebrates such as nematodes and earthworms suggest that other mechanisms of metallothionein induction may be present. A detailed study of Cd tolerance was done for a species of soil‐living springtail, \u003Cjats:italic>Orchesella cincta.\u003C/jats:italic> The metallothionein gene of this species is overexpressed in metal‐exposed field populations. Analysis of the metallothionein promoter has demonstrated extensive polymorphisms that have a functional significance, as shown in bioreporter assays. In a study comparing 20 different populations, the frequency of a high‐expresser promoter allele was positively correlated with the concentration of metals in soil, especially Cd. The springtail study shows that \u003Cjats:italic>cis\u003C/jats:italic>‐regulatory change of genes involved in the cellular stress response may contribute to evolution of metal tolerance.\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title>\u003Cjats:p>Kể từ khi cách mạng sinh học phân tử diễn ra, kiến thức của chúng ta về các cơ chế phân tử nằm dưới các cơ chế phòng vệ chống lại căng thẳng đã được mở rộng đáng kể. Dưới áp lực chọn lọc mạnh mẽ, nhiều loài động vật có thể tiến hóa để cải thiện khả năng chịu đựng căng thẳng. Điều này có thể đạt được bằng cách thay đổi cấu trúc protein (thông qua các đột biến trong các vùng mã hóa của gen) hoặc bằng cách thay đổi lượng protein (thông qua sự điều chỉnh phiên mã). Loại tiến hóa sau có thể đạt được thông qua việc thay thế trong vùng điều khiển của gen quan tâm (\u003Cjats:italic>thay đổi cis\u003C/jats:italic>) hoặc bằng cách thay đổi cấu trúc hoặc lượng của các protein điều hòa phiên mã (\u003Cjats:italic>thay đổi trans\u003C/jats:italic>). Hệ thống metallothionein là một trong những hệ thống phản ứng căng thẳng được nghiên cứu nhiều nhất trong ngữ cảnh kim loại nặng. Biểu hiện metallothionein được cho là được điều chỉnh bởi yếu tố phiên mã kim loại 1 (MTF-1); tuy nhiên, cho đến nay, sự tham gia của MTF-1 chỉ được chứng minh cho một số loài động vật có xương sống và \u003Cjats:italic>Drosophila.\u003C/jats:italic> Dữ liệu trên động vật không xương sống như giun tròn và giun đất cho thấy rằng có thể có các cơ chế khác để kích thích metallothionein. Một nghiên cứu chi tiết về khả năng chịu đựng Cd đã được thực hiện cho một loài giun đất sống trong đất, \u003Cjats:italic>Orchesella cincta.\u003C/jats:italic> Gen metallothionein của loài này được biểu hiện quá mức trong các quần thể ngoài tự nhiên tiếp xúc với kim loại. Phân tích vùng điều khiển metallothionein đã chứng minh sự đa hình sinh học rộng rãi có ý nghĩa chức năng, như đã được chứng minh qua các thí nghiệm sinh học. Trong một nghiên cứu so sánh 20 quần thể khác nhau, tần suất của một alen vùng điều khiển biểu hiện cao có mối tương quan tích cực với nồng độ kim loại trong đất, đặc biệt là Cd. Nghiên cứu về giun đất cho thấy rằng \u003Cjats:italic>thay đổi cis\u003C/jats:italic> trong việc điều chỉnh các gen liên quan đến phản ứng căng thẳng của tế bào có thể góp phần vào sự tiến hóa khả năng chịu đựng kim loại.",{"EN":4554,"VI":4555},"Molecular mechanisms of heavy metal tolerance and evolution in invertebrates","Cơ chế phân tử của khả năng chịu đựng kim loại nặng và sự tiến hóa ở động vật không xương sống",{"VOID":4557},"10.1111/j.1744-7917.2009.00249.x",[388],[390],"https://onlinelibrary.wiley.com/doi/10.1111/j.1744-7917.2009.00249.x",[4562,4584,4601],{"id":4563,"sortIndex":25,"researcher":24,"roles":4564,"affiliations":4565,"properties":4577},"6e29682f-f3da-4f2e-8068-26e70b83c679",[],[4566],{"id":4567,"sortIndex":25,"affiliation":4568,"properties":24},"81d7d2e3-5fd3-442d-a027-3aaf7c67e0d9",{"id":4569,"createTime":4570,"updateTime":4571,"relativeEntities":4572,"slug":4573,"properties":4574,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},"20094867-cd29-48ab-94af-0f81190de87b","2023-12-18T09:33:58.260+00:00","2024-10-01T20:48:23.621+00:00",[],"Department-of-Animal-Ecology-Institute-of-Ecological-Science-VU-University-Amsterdam-The-Netherlands",{"title":4575},{"VI":4576},"Department of Animal Ecology, Institute of Ecological Science, VU University, Amsterdam, The Netherlands",{"openalex":4578,"orcid":4580,"title":4582},{"VOID":4579},"A5082274663",{"VOID":4581},"https://orcid.org/0000-0003-2418-8979",{"EN":4583},"Thierry Janssens",{"id":4585,"sortIndex":110,"researcher":24,"roles":4586,"affiliations":4587,"properties":4594},"d95e2134-89e7-4391-b080-0eea10dbd9a2",[],[4588],{"id":4589,"sortIndex":25,"affiliation":4590,"properties":24},"6aea4e45-19b9-4eb4-ad3c-9e483ed2f5dd",{"id":4569,"createTime":4570,"updateTime":4571,"relativeEntities":4591,"slug":4573,"properties":4592,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4593},{"VI":4576},{"openalex":4595,"orcid":4597,"title":4599},{"VOID":4596},"A5023955946",{"VOID":4598},"https://orcid.org/0000-0003-3954-3590",{"EN":4600},"Dick Roelofs",{"id":4602,"sortIndex":123,"researcher":24,"roles":4603,"affiliations":4604,"properties":4611},"d093c574-1749-49d1-9a35-fcb008f178b1",[],[4605],{"id":4606,"sortIndex":25,"affiliation":4607,"properties":24},"36583d89-9946-4bf4-ae19-d900d81bf473",{"id":4569,"createTime":4570,"updateTime":4571,"relativeEntities":4608,"slug":4573,"properties":4609,"entityType":100,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25},[],{"title":4610},{"VI":4576},{"openalex":4612,"orcid":4614,"title":4616},{"VOID":4613},"A5071721587",{"VOID":4615},"https://orcid.org/0000-0003-4219-7297",{"EN":4617},"Nico M. van Straalen",{"url":24,"publisher":4619,"properties":4678},{"id":4620,"createTime":4621,"updateTime":4622,"relativeEntities":4623,"slug":4624,"properties":4625,"entityType":264,"verifyStatus":386,"verifyTime":24,"verifyNote":24,"syncStatus":386,"languages":24,"translateLanguages":24,"viewCount":25,"subjectFields":4635,"manageAffiliations":4636,"indexDatabases":4637,"url":4662,"thumbnailPath":24,"statistic":4663,"gsStatistic":24,"type":24,"analyzePriority":24},"004731bd-231f-4422-a923-330a3f883edc","2023-05-29T10:35:17.129+00:00","2025-01-14T07:36:23.279+00:00",[],"Insect-Science",{"country":4626,"issn":4627,"introduce":4629,"eissn":4631,"title":4633},{"VOID":1248},{"VOID":4628},"17447917",{"EN":4630},"Insect Science is an English-language journal, which publishes original research articles dealing with all fields of research in into insects and other terrestrial arthropods. Papers in any of the following fields will be considered: ecology, behavior, biogeography, physiology, biochemistry, sociobiology, phylogeny, pest management, and exotic incursions. The emphasis of the journal is on the adaptation and evolutionary biology of insects from the molecular to the ecosystem level. Reviews, mini reviews and letters to the editor, book reviews, and information about academic activities of the society are also published.",{"VOID":4632},"16729609",{"EN":4634},"Insect 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